biostudies-literatureStaneva DEuropean Union Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria5570https://www.ebi.ac.uk/biostudies/studies/S-EPMC12734544biostudies-literatureUnknown18(24)The article describes the interaction between 4-amino-1,8-naphthalic anhydride and the terminal amine groups of the first-generation poly(amidoamine) (PAMAM) dendrimer. Cotton fabric was treated with the newly obtained photoactive dendrimer (DA) to achieve its antimicrobial photodynamic inactivation. The photodynamic inactivation method is an innovative approach in which, upon irradiation with visible light, photosensitizers generate highly reactive oxygen species, specifically singlet oxygen (<sup>1</sup>O<sub>2</sub>), which destroys microbial cells. In the dark, the DA dendrimer strongly inhibits the development of the model bacteria Bacillus cereus (a Gram-positive bacterium) and Pseudomonas aeruginosa (a Gram-negative bacterium) in solution. Upon irradiation with visible light, the inMaterials (Basel, Switzerland)Photodynamic Microbial Defense of Cotton Fabric with 4-Amino-1,8-naphthalimide-Labeled PAMAM Dendrimer.PMC12734544BG-RRP-2.004-0002, "BiOrgaMCT"BG-RRP-2.004-0008Staneva DAtanasova DGrabchev IfalsePhotodynamic Microbial Defense of Cotton Fabric with 4-Amino-1,8-naphthalimide-Labeled PAMAM Dendrimer.The article describes the interaction between 4-amino-1,8-naphthalic anhydride and the terminal amine groups of the first-generation poly(amidoamine) (PAMAM) dendrimer. Cotton fabric was treated with the newly obtained photoactive dendrimer (DA) to achieve its antimicrobial photodynamic inactivation. The photodynamic inactivation method is an innovative approach in which, upon irradiation with visible light, photosensitizers generate highly reactive oxygen species, specifically singlet oxygen (<sup>1</sup>O<sub>2</sub>), which destroys microbial cells. In the dark, the DA dendrimer strongly inhibits the development of the model bacteria Bacillus cereus (a Gram-positive bacterium) and Pseudomonas aeruginosa (a Gram-negative bacterium) in solution. Upon irradiation with visible light, the in2025-01-01T00:00:00Z2025 Dec2026-05-27T03:18:51.393Z2026-05-27T03:11:56.14ZS-EPMC127345444147034310.3390/ma18245570