biostudies-literatureUnknown61(12)Brugiatelli LInfective endocarditis (IE) is a life-threatening condition with a rising incidence, demanding rapid and precise diagnosis. While echocardiography remains the cornerstone of initial evaluation, its limitations in complex cases-such as those involving prosthetic valves or cardiac devices-are well-known. This review synthesizes current evidence and guidelines to outline a practical, multimodality imaging approach for IE. We emphasize that integrating advanced techniques like cardiac computed tomography (CT) and [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) early in the diagnostic pathway, particularly in high-risk scenarios, significantly enhances diagnostic certainty, guides therapeutic decisions, and improves patient outcomes. A tailored imaging strMedicina (Kaunas, Lithuania)2241https://www.ebi.ac.uk/biostudies/studies/S-EPMC12735077biostudies-literatureMultimodality Imaging in Infective Endocarditis: A Clinical Approach to Diagnosis.PMC12735077Enrico PCapodaglio IBrugiatelli LMarco NSimone LPatani FBenedetta AGiulia PMarco FMarco MLofiego CMarco DEVagnarelli FBenedetti MNicolo SArianna MMaurizi KAntonio DRGiulia FChiara GGiovanni TMatteo FfalseMultimodality Imaging in Infective Endocarditis: A Clinical Approach to Diagnosis.Infective endocarditis (IE) is a life-threatening condition with a rising incidence, demanding rapid and precise diagnosis. While echocardiography remains the cornerstone of initial evaluation, its limitations in complex cases-such as those involving prosthetic valves or cardiac devices-are well-known. This review synthesizes current evidence and guidelines to outline a practical, multimodality imaging approach for IE. We emphasize that integrating advanced techniques like cardiac computed tomography (CT) and [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) early in the diagnostic pathway, particularly in high-risk scenarios, significantly enhances diagnostic certainty, guides therapeutic decisions, and improves patient outcomes. A tailored imaging str2025-01-01T00:00:00Z2025 Dec2026-05-27T08:01:45.984Z2026-05-27T03:12:33.158ZS-EPMC127350774147024210.3390/medicina61122241