biostudies-literatureUnknown18(12)Minutti-Calva YBackground:Equisetum hyemale L., commonly known as scouring rush or horsetail, is a perennial plant with significant applications in traditional medicine. Methods: The aerial parts of E. hyemale L. were macerated with hexane, chloroform, and ethyl acetate. The phytochemical profile of the extracts was investigated using chromatography approaches. The biological performance of the extracts was determined using antibacterial, antioxidant, anticancer, and toxicity in vitro and in vivo models. Molecular docking and ADMET analyses were employed to determine interactions with structural components of multidrug resistant bacteria and assess potential toxicological risks. Results: The extracts exert high scavenging activity against ABTS radicals (IC50 Pharmaceuticals (Basel, Switzerland)1901https://www.ebi.ac.uk/biostudies/studies/S-EPMC12736147biostudies-literatureEquisetum hyemale L. Extracts: Phytochemistry, Biological Performance, ADMET Profiling, and Toxicity Predictions.PMC12736147Navarro-Lopez DESanchez-Arreola EDel Razo-Rodriguez OESilva-Jara JMChavez-Tinoco MLopez-Mena ERLozada-Ramirez JDMejia-Mendez JLReza-Zaldivar EEMinutti-Calva YVitola ISchurenkamper-Carrillo KJacobo-Velazquez DAfalseEquisetum hyemale L. Extracts: Phytochemistry, Biological Performance, ADMET Profiling, and Toxicity Predictions.Background:Equisetum hyemale L., commonly known as scouring rush or horsetail, is a perennial plant with significant applications in traditional medicine. Methods: The aerial parts of E. hyemale L. were macerated with hexane, chloroform, and ethyl acetate. The phytochemical profile of the extracts was investigated using chromatography approaches. The biological performance of the extracts was determined using antibacterial, antioxidant, anticancer, and toxicity in vitro and in vivo models. Molecular docking and ADMET analyses were employed to determine interactions with structural components of multidrug resistant bacteria and assess potential toxicological risks. Results: The extracts exert high scavenging activity against ABTS radicals (IC50 2025-01-01T00:00:00Z2025 Dec2026-05-28T03:15:56.699Z2026-05-28T03:10:52.246ZS-EPMC127361474147139010.3390/ph18121901