{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng X"],"funding":["the CAMS Innovation Fund for Medical Sciences","the Beijing Natural Science Foundation"],"pagination":["1512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12736233"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["<b>Background/Objectives</b>: Dihydroquercetin, known for its broad biological activities, is a key component in dietary supplements and functional foods. This study aims to identify its novel pure solid forms, advancing understanding of its physicochemical properties and polymorphism. <b>Methods</b>: Systematic screening, preparation, and characterization efforts identified five solvates: dihydroquercetin monohydrate (1:1, S1 and S2), sesquihydrate (1:1.5, S3), dihydrate (1:2, S4), and ACN solvate (1:1, S5), along with one solvent-free phase (S6). <b>Results</b>: The crystal structures of the five solvates were successfully elucidated for the first time. A comprehensive suite of techniques, including single-crystal and powder X-ray diffraction, DSC, TG, and FT-IR, were employed to charact"],"journal":["Pharmaceutics"],"pubmed_title":["X-Ray Structures, Intermolecular Interactions, and Structural Transformations of Dihydroquercetin Solvates and Polymorphs."],"pmcid":["PMC12736233"],"funding_grant_id":["No. 7222261","No.2022-I2M-1-015"],"pubmed_authors":["Zou Y","Lu Y","Xing C","Gong N","Du G","Yang S","Meng X"],"additional_accession":[]},"is_claimable":false,"name":"X-Ray Structures, Intermolecular Interactions, and Structural Transformations of Dihydroquercetin Solvates and Polymorphs.","description":"<b>Background/Objectives</b>: Dihydroquercetin, known for its broad biological activities, is a key component in dietary supplements and functional foods. This study aims to identify its novel pure solid forms, advancing understanding of its physicochemical properties and polymorphism. <b>Methods</b>: Systematic screening, preparation, and characterization efforts identified five solvates: dihydroquercetin monohydrate (1:1, S1 and S2), sesquihydrate (1:1.5, S3), dihydrate (1:2, S4), and ACN solvate (1:1, S5), along with one solvent-free phase (S6). <b>Results</b>: The crystal structures of the five solvates were successfully elucidated for the first time. A comprehensive suite of techniques, including single-crystal and powder X-ray diffraction, DSC, TG, and FT-IR, were employed to charact","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-27T08:04:21.379Z","creation":"2026-05-27T03:12:29.42Z"},"accession":"S-EPMC12736233","cross_references":{"pubmed":["41471028"],"doi":["10.3390/pharmaceutics17121512"]}}