{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Romero H"],"funding":["FIC NIH HHS","NIGMS NIH HHS"],"pagination":["R66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1273633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(8)"],"pubmed_abstract":["<h4>Background</h4>The essential trace element selenium is used in a wide variety of biological processes. Selenocysteine (Sec), the 21st amino acid, is co-translationally incorporated into a restricted set of proteins. It is encoded by an UGA codon with the help of tRNASec (SelC), Sec-specific elongation factor (SelB) and a cis-acting mRNA structure (SECIS element). In addition, Sec synthase (SelA) and selenophosphate synthetase (SelD) are involved in the biosynthesis of Sec on the tRNASec. Selenium is also found in the form of 2-selenouridine, a modified base present in the wobble position of certain tRNAs, whose synthesis is catalyzed by YbbB using selenophosphate as a precursor.<h4>Results</h4>We analyzed completely sequenced genomes for occurrence of the selA, B, C, D and ybbB genes. "],"journal":["Genome biology"],"pubmed_title":["Evolution of selenium utilization traits."],"pmcid":["PMC1273633"],"funding_grant_id":["R01 GM061603","R03 TW006959","TW006959","GM061603"],"pubmed_authors":["Romero H","Zhang Y","Gladyshev VN","Salinas G"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of selenium utilization traits.","description":"<h4>Background</h4>The essential trace element selenium is used in a wide variety of biological processes. Selenocysteine (Sec), the 21st amino acid, is co-translationally incorporated into a restricted set of proteins. It is encoded by an UGA codon with the help of tRNASec (SelC), Sec-specific elongation factor (SelB) and a cis-acting mRNA structure (SECIS element). In addition, Sec synthase (SelA) and selenophosphate synthetase (SelD) are involved in the biosynthesis of Sec on the tRNASec. Selenium is also found in the form of 2-selenouridine, a modified base present in the wobble position of certain tRNAs, whose synthesis is catalyzed by YbbB using selenophosphate as a precursor.<h4>Results</h4>We analyzed completely sequenced genomes for occurrence of the selA, B, C, D and ybbB genes. ","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005","modification":"2025-04-19T20:53:07.043Z","creation":"2019-03-27T01:25:23Z"},"accession":"S-EPMC1273633","cross_references":{"pubmed":["16086848"],"doi":["10.1186/gb-2005-6-8-r66"]}}