biostudies-literatureBivona MNextGeneration EU- MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases1285https://www.ebi.ac.uk/biostudies/studies/S-EPMC12736331biostudies-literatureUnknown14(12)<i>Salmonella</i> is a Gram-negative enteric bacterium responsible for the foodborne and waterborne disease salmonellosis, which was the second most reported foodborne gastrointestinal infection in humans in the European Union in 2023. Animals represent the principal reservoir of this pathogen, with animal-derived food products serving as the main route of transmission to humans. In a household context, having numerous animals can be a crucial factor for contracting <i>Salmonella</i> spp. infection. In the present study, we report a case of a familiar outbreak of <i>Salmonella</i> Thompson that occurred in 2024 in central Italy, involving an infant and the companion animals (a dog, a cat and ten birds) of the family's farm. To support the epidemiological investigations, antimicrobial suscePathogens (Basel, Switzerland)One Health Investigation of a Household <i>Salmonella</i> Thompson Outbreak in Italy: Genomic and Epidemiological Characterization of an Emerging Serotype.PMC12736331project no. PE00000007, PE13 INFACT, Nodes 3 and 4Di Domenico IRiccardi FCarfora VCordaro GBivona MRussini VAdreani GDi Blasi LDe Marchis MLBossu TDe Bene AFCampeis FMarconi PSenese MMiddei BGasperetti LfalseOne Health Investigation of a Household <i>Salmonella</i> Thompson Outbreak in Italy: Genomic and Epidemiological Characterization of an Emerging Serotype.<i>Salmonella</i> is a Gram-negative enteric bacterium responsible for the foodborne and waterborne disease salmonellosis, which was the second most reported foodborne gastrointestinal infection in humans in the European Union in 2023. Animals represent the principal reservoir of this pathogen, with animal-derived food products serving as the main route of transmission to humans. In a household context, having numerous animals can be a crucial factor for contracting <i>Salmonella</i> spp. infection. In the present study, we report a case of a familiar outbreak of <i>Salmonella</i> Thompson that occurred in 2024 in central Italy, involving an infant and the companion animals (a dog, a cat and ten birds) of the family's farm. To support the epidemiological investigations, antimicrobial susce2025-01-01T00:00:00Z2025 Dec2026-05-28T03:18:18.74Z2026-05-28T03:11:28.523ZS-EPMC127363314147124010.3390/pathogens14121285