{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Okoye C"],"funding":["Ageing Well in an Ageing Society","National Recovery and Resilience Plan","Next Generation EU"],"pagination":["S180-S188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12737002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80(Supplement_2)"],"pubmed_abstract":["<h4>Objectives</h4>Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings.<h4>Methods</h4>Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform.<h4>Results</h4>The project is expected to generate evidence on"],"journal":["The journals of gerontology. Series B, Psychological sciences and social sciences"],"pubmed_title":["Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program."],"pmcid":["PMC12737002"],"funding_grant_id":["DM 1557"],"pubmed_authors":["Locati S","Finazzi A","Gasparini F","Natalello A","Villari P","Leone A","Zoia CP","Custodero C","Dibello V","Silanos F","Delussi M","Brattico E","De Luca A","Massimi A","Noale M","Zambon A","Airoldi C","Paragliola G","Calciolari S","Bruno G","Logroscino G","Pegoraro S","Romano D","Siciliano P","Chicco D","Solfrizzi V","Tremolizzo L","Lenti R","Cincotti F","Spoke 8 Age-It Working Group","Daini R","Moretti L","Tosi G","Ceolin C","Matteini P","Canevelli M","Saibene A","Pirrelli V","Pozzi FE","Quaranta NAA","Capone S","Di Napoli C","Ferrarese C","Colamarino E","Grossi A","Franchi M","Ribino P","Romeo Z","Goldin E","Cuffaro L","Bazzini C","Conti E","Okoye C","Pagan E","Tratsevich A","Macchia E","Ferrara MC","Corsonello A","Sala G","Cortelessa G","Paparella G","Bellelli G","Crudele L","Riccardi G","Sciurti E","Bologna M","Gesualdo L","Aloisi A","Maggi S","Bulgari M","Bochicchio MA","Francioso L","Orlandi I","Chiaradonna F","Sala A","Vezzoso A","Logrieco A","Luca S","Ganora D","Messina G","Appollonio I","Isella V","Tamburrano A","Mantuano P"],"additional_accession":[]},"is_claimable":false,"name":"Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program.","description":"<h4>Objectives</h4>Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings.<h4>Methods</h4>Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform.<h4>Results</h4>The project is expected to generate evidence on","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T03:18:34.394Z","creation":"2026-06-04T03:12:06.28Z"},"accession":"S-EPMC12737002","cross_references":{"pubmed":["41442763"],"doi":["10.1093/geronb/gbaf186"]}}