biostudies-literatureOkoye CAgeing Well in an Ageing SocietyNational Recovery and Resilience PlanNext Generation EUS180-S188https://www.ebi.ac.uk/biostudies/studies/S-EPMC12737002biostudies-literatureUnknown80(Supplement_2)<h4>Objectives</h4>Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings.<h4>Methods</h4>Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform.<h4>Results</h4>The project is expected to generate evidence onThe journals of gerontology. Series B, Psychological sciences and social sciencesMulticomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program.PMC12737002DM 1557Locati SFinazzi AGasparini FNatalello AVillari PLeone AZoia CPCustodero CDibello VSilanos FDelussi MBrattico EDe Luca AMassimi ANoale MZambon AAiroldi CParagliola GCalciolari SBruno GLogroscino GPegoraro SRomano DSiciliano PChicco DSolfrizzi VTremolizzo LLenti RCincotti FSpoke 8 Age-It Working GroupDaini RMoretti LTosi GCeolin CMatteini PCanevelli MSaibene APirrelli VPozzi FEQuaranta NAACapone SDi Napoli CFerrarese CColamarino EGrossi AFranchi MRibino PRomeo ZGoldin ECuffaro LBazzini CConti EOkoye CPagan ETratsevich AMacchia EFerrara MCCorsonello ASala GCortelessa GPaparella GBellelli GCrudele LRiccardi GSciurti EBologna MGesualdo LAloisi AMaggi SBulgari MBochicchio MAFrancioso LOrlandi IChiaradonna FSala AVezzoso ALogrieco ALuca SGanora DMessina GAppollonio IIsella VTamburrano AMantuano PfalseMulticomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program.<h4>Objectives</h4>Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings.<h4>Methods</h4>Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform.<h4>Results</h4>The project is expected to generate evidence on2025-01-01T00:00:00Z2025 Dec2026-06-04T03:18:34.394Z2026-06-04T03:12:06.28ZS-EPMC127370024144276310.1093/geronb/gbaf186