{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dinh CT"],"funding":["Vietnam Ministry of Science and Technology"],"pagination":["1578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12737151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["<b>Background:</b> Conventional insulin injections cannot mimic physiological pancreatic function and often lead to dangerous hypoglycemic events that glucose-responsive systems aim to prevent. Glucose-responsive microneedles (MNs) offer a promising closed-loop alternative. We developed an enzyme-free, glucose-responsive MN patch composed of a PVA/Dextran hydrogel dynamically crosslinked with borax, and evaluated its performance, biosafety, and in vivo efficacy. <b>Methods:</b> MNs were fabricated from PVA/Dextran via micromolding and crosslinked with borax. The formulation was systematically optimized based on mechanical properties and glucose-responsive release kinetics. Physicochemical properties, biosafety (cytotoxicity, skin barrier recovery, boron leaching), and in vivo efficacy in a"],"journal":["Pharmaceutics"],"pubmed_title":["Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation."],"pmcid":["PMC12737151"],"funding_grant_id":["ĐTĐLCN.68/22"],"pubmed_authors":["Dinh CT","Nguyen DT","Doan TD","Nguyen LP","Pham UT","Do HTM","Nguyen AM","Luu PD","Bui MTH","Tran TQ"],"additional_accession":[]},"is_claimable":false,"name":"Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation.","description":"<b>Background:</b> Conventional insulin injections cannot mimic physiological pancreatic function and often lead to dangerous hypoglycemic events that glucose-responsive systems aim to prevent. Glucose-responsive microneedles (MNs) offer a promising closed-loop alternative. We developed an enzyme-free, glucose-responsive MN patch composed of a PVA/Dextran hydrogel dynamically crosslinked with borax, and evaluated its performance, biosafety, and in vivo efficacy. <b>Methods:</b> MNs were fabricated from PVA/Dextran via micromolding and crosslinked with borax. The formulation was systematically optimized based on mechanical properties and glucose-responsive release kinetics. Physicochemical properties, biosafety (cytotoxicity, skin barrier recovery, boron leaching), and in vivo efficacy in a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-28T03:14:21.093Z","creation":"2026-05-28T03:07:05.235Z"},"accession":"S-EPMC12737151","cross_references":{"pubmed":["41471093"],"doi":["10.3390/pharmaceutics17121578"]}}