{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lyu M"],"funding":["National Key Research and Development Program of China"],"pagination":["1031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12737239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["Total ammonia nitrogen (TAN) is a common and potent neurotoxic pollutant in aquatic environments. Due to their strong adsorption capacity, titanium dioxide nanoparticles (n-TiO<sub>2</sub>), a widely used engineered material, can induce combined toxicity with multiple pollutants. However, the combined neurotoxicity of n-TiO<sub>2</sub> and TAN and its underlying mechanisms remain unclear. In this study, zebrafish embryos were exposed to TAN (0, 0.1, 1, 10 mg/L) and n-TiO<sub>2</sub> (100 µg/L) individually or in combination for 120 h. The results indicated that co-exposure to n-TiO<sub>2</sub> and TAN significantly increased the bioaccumulation of TAN in zebrafish embryos compared to TAN alone. Consequently, this led to exacerbated neurotoxicity, manifested as developmental impairments and"],"journal":["Toxics"],"pubmed_title":["Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos."],"pmcid":["PMC12737239"],"funding_grant_id":["2022YFC3203905"],"pubmed_authors":["Liu H","Liu X","Zou X","Li G","Lyu M","Shi F","Ma X","Zha J","Yang Q","Wang X","Yu J","Shen Y"],"additional_accession":[]},"is_claimable":false,"name":"Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos.","description":"Total ammonia nitrogen (TAN) is a common and potent neurotoxic pollutant in aquatic environments. Due to their strong adsorption capacity, titanium dioxide nanoparticles (n-TiO<sub>2</sub>), a widely used engineered material, can induce combined toxicity with multiple pollutants. However, the combined neurotoxicity of n-TiO<sub>2</sub> and TAN and its underlying mechanisms remain unclear. In this study, zebrafish embryos were exposed to TAN (0, 0.1, 1, 10 mg/L) and n-TiO<sub>2</sub> (100 µg/L) individually or in combination for 120 h. The results indicated that co-exposure to n-TiO<sub>2</sub> and TAN significantly increased the bioaccumulation of TAN in zebrafish embryos compared to TAN alone. Consequently, this led to exacerbated neurotoxicity, manifested as developmental impairments and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-08T03:11:22.987Z","creation":"2026-06-08T03:08:11.267Z"},"accession":"S-EPMC12737239","cross_references":{"pubmed":["41441252"],"doi":["10.3390/toxics13121031"]}}