{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shiroshita A"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIEHS NIH HHS","NIH HHS"],"pagination":["e443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12737862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Children encounter multiple indoor and outdoor environmental exposures in early life. We assessed the independent effects of indoor home exposures and ambient particulate matter with an aerodynamic diameter ≤2.5 µm (PM<sub>2.5</sub>) on early childhood asthma diagnosis.<h4>Methods</h4>We included 6,413 children born 1987-2016 from nine United States prospective birth cohorts from the Environmental Influences on Child Health Outcomes consortium, with complete covariate and outcome data. Exposures were (1) average ambient PM<sub>2.5</sub> levels during the first 3 years of life, and (2) indoor home exposures, including water damage/home dampness during infancy/childhood, dogs/cats at home during infancy, dust mite allergen during infancy/childhood. Asthma was defined as ca"],"journal":["Environmental epidemiology (Philadelphia, Pa.)"],"pubmed_title":["Individual and combined effects of indoor home exposures and ambient PM&lt;sub&gt;2.5&lt;/sub&gt; during early life on childhood asthma in us birth cohort studies."],"pmcid":["PMC12737862"],"funding_grant_id":["UL1 TR002243","UG3 OD035516","P30 ES020957","P30 ES000002","U19 AI095227","UH3 OD023286","U24 AI179612","UG3 OD035533","P01 AI089473","U2C OD023375","U24 OD023382"],"pubmed_authors":["Marsit CJ","Lewis JL","Potter JE","Rennie BJ","Brennan PA","Zoratti EM","Aguiar A","Alshawabkeh AN","O'Connor TG","Seroogy CM","Douglas C","James-Todd T","Datta S","Singh AM","Cordero JF","Taylor G","Whitworth KW","Gogcu S","Schmidt RJ","Ainsworth J","Ruden DM","Spillane NT","Magzamen S","Macy ML","Kattan M","Eiland LR","Jan S","Slaughter JL","Shah RV","Margolis A","Adair L","Carroll KN","Barrett ES","Litonjua AA","O'Shea TM","Luttmann-Gibson H","Barone CJ","Hazlett H","Young K","Farzan S","Paneth N","Haddad AS","Catellier D","Lai JS","Urquhart A","Johnson-Hooper T","Miller M","Zhu Z","Zhu Y","Zanobetti A","Hunt KJ","Santos H","Stroustrup A","D'Sa V","Eapen A","Zhao Q","Keim SA","Obeid R","Moore PE","Mosquera RA","Piven J","Ober C","Schantz SL","Dunlop AL","Porucznik CA","Check J","Oken E","Giardino AP","Hamvas A","Suri KN","Lester BM","Habre R","Altman M","Landa R","Ramratnam SK","Newby LK","Bishop S","Neiderhiser JM","McGowan EC","McGrath M","Cassidy-Bushrow A","Nozadi SS","Strakovsky R","Dager S","Thompson A","Murray T","Smith PB","O'Connor GT","DeMauro SB","Paidas MJ","Bennett DH","Msall M","Shiroshita A","Merhar SL","Jackson DJ","Kerver JM","Straughen JK","Freedman JE","Woodruff T","Coull BA","ECHO Cohort Consortium","Bear K","Tabb K","Aschner JL","Gilliland FD","Vaidya R","Olidipo AF","Frazier JA","Sidebottom AC","Blaser MJ","Hartert TV","Baumann-Blackmore N","Northrup TF","Newschaffer CJ","Fussman C","Ozonoff S","Lewis D","Ames J","Duggal P","Meirowitz N","Jensen E","MacKenzie DM","Ma T","Sullivan AF","Helderman JB","Knapp E","Reynolds Lyndaker AM","Katzow MW","Monk C","Khurana Hershey GK","Hipwell AE","Schweitzer JB","Das SR","Wegienka G","Levin A","Volk HE","Symanski E","Chiuzan C","Pandey J","Perng W","Moore BF","Jackson W","Hernandez M","Everson T","Miller RK","Morello-Frosch R","Miller RL","Avalos LA","Karagas MR","Luo L","McKennan CG","Madan JC","Woodcroft K","Hooper SR","Kress A","Horton DB","Rosen T","Bacharier LB","Tepper RS","Neal CR","Ryan PH","Blackwell CK","Meeker J","Newman RB","Wilson J","Rifas-Shiman SL","Sordillo JE","Carter BS","Venkatesh KK","Smith LM","Lemanske RF","Nguyen RH","Mansolf MA","Goldstein JA","Mithal LB","Tylavsky F","Ruby N","Ganiban JM","Maldonado I","Croen LA","Alkis MH","Palomares K","Rivera-Spoljaric K","Wilkening G","Pryhuber GS","Hudak M","Lynch CD","Stanford JB","Canino G","Burris HH","Cella D","Duthely L","Lynch SV","Johnson CC","Martinez FD","DeRegnier RO","Collett B","Gold DR","Geiger SD","Mumford SL","Blossom J","Gangnon R","Gebretsadik T","Rollins JV","Koinis Mitchell D","Ferrara A","Bush NR","Padula A","Hockett C","Loftus CT","Bendixsen CG","Montgomery A","Lugo-Candelas C","Blitz MJ","Sitarik A","Duarte CS","Mallal SA","Herbstman JB","Ownby D","Loncar CM","McLean JA","Trasande L","Shilts MH","Hershey GKK","LaSalle JM","Poindexter B","Mendez-Figueroa H","Dabelea D","Wood RA","Fisher SA","Rafael T","Rinehart DJ","Rochelson B","Singh R","Osmundson S","Elliott A","Lyall K","Hacker MR","Elliott MR","Leventhal BL","Beamer PI","McEvoy CT","Spindel ER","Ho E","Botteron K","Lu K","Pastyrnak SL","Sakai C","Wright RJ","Davidson B","LeWinn KZ","Mendonca EA","Hedderson MM","Wright RO","Hertz-Picciotto I","Lenski M","Sheinkopf SJ","Joseph RM","Wang VA","Bekelman TA","Lampland AL","Starling AP","Gern JE","Fry RC","Yee LM","Washburn LK","Weiss ST","Gershon R","Dominguez-Bello MG","Stone W","Camargo CA","Schultz R","Hasegawa K","Kim YS","Rollins C","Karr CJ","Daniels J","Bloom MS","Jacobson LP","Brown Z","Deoni SC","Roberts JR","Joseph CL","Sathyanarayana S","Leve LD","Maitre NL","Mueller HG","JaKa MM","Jimenez M","Posner J","Messinger D","Jayakumar A"],"additional_accession":[]},"is_claimable":false,"name":"Individual and combined effects of indoor home exposures and ambient PM&lt;sub&gt;2.5&lt;/sub&gt; during early life on childhood asthma in us birth cohort studies.","description":"<h4>Background</h4>Children encounter multiple indoor and outdoor environmental exposures in early life. We assessed the independent effects of indoor home exposures and ambient particulate matter with an aerodynamic diameter ≤2.5 µm (PM<sub>2.5</sub>) on early childhood asthma diagnosis.<h4>Methods</h4>We included 6,413 children born 1987-2016 from nine United States prospective birth cohorts from the Environmental Influences on Child Health Outcomes consortium, with complete covariate and outcome data. Exposures were (1) average ambient PM<sub>2.5</sub> levels during the first 3 years of life, and (2) indoor home exposures, including water damage/home dampness during infancy/childhood, dogs/cats at home during infancy, dust mite allergen during infancy/childhood. Asthma was defined as ca","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-06T20:01:34.52Z","creation":"2026-06-04T03:12:49.523Z"},"accession":"S-EPMC12737862","cross_references":{"pubmed":["41450756"],"doi":["10.1097/EE9.0000000000000443"]}}