{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yang C"],"pubmed_abstract":["ObjectiveThis study investigates the relationship between aging and histone deacetylases (HDACs) in mandibular condylar cartilage.MethodsMale C57BL/6 mice were divided into 4 age groups: postnatal day 21 (D21, postnatal development), 3 months (3M, young adulthood), 10 months (10M, middle aging), and 18 months (18M, late aging) to cover mandibular condylar cartilage aging stages. Mandibular condylar cartilage specimens were harvested and paraffin-embedded. Hematoxylin-eosin (H&E) and Safranin O-fast green staining were performed to assess morphological changes. Immunohistochemistry (IHC) was applied to map the spatiotemporal expression of the HDAC1-11 in condylar cartilage.ResultsHDAC1, HDAC6, HDAC7, and HDAC9 were undetected in the mandibular condylar cartilage. HDAC2, 3, 4, 8, and 10 were"],"journal":["Cartilage"],"pagination":["19476035251407304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12743641"],"repository":["biostudies-literature"],"pubmed_title":["Stage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage."],"pmcid":["PMC12743641"],"pubmed_authors":["Wang M","Li H","Guo X","Kong J","Yang C","Wang J","Zhan Y"],"additional_accession":[]},"is_claimable":false,"name":"Stage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage.","description":"ObjectiveThis study investigates the relationship between aging and histone deacetylases (HDACs) in mandibular condylar cartilage.MethodsMale C57BL/6 mice were divided into 4 age groups: postnatal day 21 (D21, postnatal development), 3 months (3M, young adulthood), 10 months (10M, middle aging), and 18 months (18M, late aging) to cover mandibular condylar cartilage aging stages. Mandibular condylar cartilage specimens were harvested and paraffin-embedded. Hematoxylin-eosin (H&E) and Safranin O-fast green staining were performed to assess morphological changes. Immunohistochemistry (IHC) was applied to map the spatiotemporal expression of the HDAC1-11 in condylar cartilage.ResultsHDAC1, HDAC6, HDAC7, and HDAC9 were undetected in the mandibular condylar cartilage. HDAC2, 3, 4, 8, and 10 were","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-08T05:41:33.081Z","creation":"2026-06-08T03:09:09.571Z"},"accession":"S-EPMC12743641","cross_references":{"pubmed":["41454645"],"doi":["10.1177/19476035251407304"]}}