biostudies-literatureUnknownYang CObjectiveThis study investigates the relationship between aging and histone deacetylases (HDACs) in mandibular condylar cartilage.MethodsMale C57BL/6 mice were divided into 4 age groups: postnatal day 21 (D21, postnatal development), 3 months (3M, young adulthood), 10 months (10M, middle aging), and 18 months (18M, late aging) to cover mandibular condylar cartilage aging stages. Mandibular condylar cartilage specimens were harvested and paraffin-embedded. Hematoxylin-eosin (H&E) and Safranin O-fast green staining were performed to assess morphological changes. Immunohistochemistry (IHC) was applied to map the spatiotemporal expression of the HDAC1-11 in condylar cartilage.ResultsHDAC1, HDAC6, HDAC7, and HDAC9 were undetected in the mandibular condylar cartilage. HDAC2, 3, 4, 8, and 10 wereCartilage19476035251407304https://www.ebi.ac.uk/biostudies/studies/S-EPMC12743641biostudies-literatureStage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage.PMC12743641Wang MLi HGuo XKong JYang CWang JZhan YfalseStage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage.ObjectiveThis study investigates the relationship between aging and histone deacetylases (HDACs) in mandibular condylar cartilage.MethodsMale C57BL/6 mice were divided into 4 age groups: postnatal day 21 (D21, postnatal development), 3 months (3M, young adulthood), 10 months (10M, middle aging), and 18 months (18M, late aging) to cover mandibular condylar cartilage aging stages. Mandibular condylar cartilage specimens were harvested and paraffin-embedded. Hematoxylin-eosin (H&E) and Safranin O-fast green staining were performed to assess morphological changes. Immunohistochemistry (IHC) was applied to map the spatiotemporal expression of the HDAC1-11 in condylar cartilage.ResultsHDAC1, HDAC6, HDAC7, and HDAC9 were undetected in the mandibular condylar cartilage. HDAC2, 3, 4, 8, and 10 were2025-01-01T00:00:00Z2025 Dec2026-06-08T05:41:33.081Z2026-06-08T03:09:09.571ZS-EPMC127436414145464510.1177/19476035251407304