biostudies-literatureUnknown9(1)Parikh T<h4>Background and aims</h4>Bilirubin, an antioxidant and anti-inflammatory agent, has been shown to negatively correlate with adiposity. However, the extent to which adiposity level influences total bilirubin (TBili) concentration remains unclear. We sought to evaluate the associations of body mass index (BMI; kg/m²) and waist circumference (WC) with low TBili concentration.<h4>Methods</h4>We included adults ≥ 20 years of age without elevated liver enzymes, excess alcohol use, iron overload, anemia, TBili ≥ 1.2 mg/dL, low albumin, or positive hepatitis serology from the 1999-2018 National Health and Nutrition Examination Survey. The primary outcome was low TBili, defined as < 0.4 mg/dL. We used multivariable logistic regression to determine the odds ratios of low TBili by BMI and WC categHealth science reportse71700https://www.ebi.ac.uk/biostudies/studies/S-EPMC12745926biostudies-literatureAssociation Between Adiposity and Low Total Serum Bilirubin Concentration: A Retrospective, Cross-Sectional Study.PMC12745926Reddy SIslam SParikh TGoradia EHameed FVisaria AVemulapalli BfalseAssociation Between Adiposity and Low Total Serum Bilirubin Concentration: A Retrospective, Cross-Sectional Study.<h4>Background and aims</h4>Bilirubin, an antioxidant and anti-inflammatory agent, has been shown to negatively correlate with adiposity. However, the extent to which adiposity level influences total bilirubin (TBili) concentration remains unclear. We sought to evaluate the associations of body mass index (BMI; kg/m²) and waist circumference (WC) with low TBili concentration.<h4>Methods</h4>We included adults ≥ 20 years of age without elevated liver enzymes, excess alcohol use, iron overload, anemia, TBili ≥ 1.2 mg/dL, low albumin, or positive hepatitis serology from the 1999-2018 National Health and Nutrition Examination Survey. The primary outcome was low TBili, defined as < 0.4 mg/dL. We used multivariable logistic regression to determine the odds ratios of low TBili by BMI and WC categ2026-01-01T00:00:00Z2026 Jan2026-06-06T09:35:32.767Z2026-05-28T03:11:43.405ZS-EPMC127459264147377310.1002/hsr2.71700