{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu Z"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","Science for Life Laboratory","Burroughs Wellcome Fund","Harvard Medical School","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","Stanford University","Massachusetts General Hospital (MGH)","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)","Burroughs Wellcome Fund (BWF)","Science for Life Laboratory (SciLifeLab)","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","American Heart Association","Massachusetts General Hospital","NIDDK NIH HHS","Fondation Leducq","NIMHD NIH HHS","U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)","NHGRI NIH HHS","U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute","American Heart Association (American Heart Association, Inc.)"],"pagination":["11688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12748892"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations show substantial heterogeneity by driver genes, sex, and race, and were enriched for immun"],"journal":["Nature communications"],"pubmed_title":["Human plasma proteomic profile of clonal hematopoiesis."],"pmcid":["PMC12748892"],"funding_grant_id":["75N92022D00003","75N92022D00004","75N92022D00001","RC2 HL102419","R01 HL151283","75N92022D00002","R01 MH104964 and R01 MH123451","R00 HG012956","R01DK125782","75N92022D00005","R01 AG023629","Burroughs Wellcome Foundation Career Award for Medical Scientists","HHSN268201600003C","HHSN268201800010I","R01 HL151152","1R01HL134892 and 1R01HL163099-01","R01 HL120393","U54 HG003067","HHSN268200800007C","N01 HC055222","R01 MH123451","R01 HL135242","K08HL161445","P30 DK063491","HHSN268201600004C","R01 HL148050","U01 HG004402","UL1 TR001420","R01 HL134320","U01 HL080295","R01 HL117626","75N98025D00022","75N98025D00025","R01 HL163099","75N98025D00024","75N98025D00027","75N98025D00026","75N98025D00028","DP2 HL157540","R01HL142711, R01HL127564, R01HL148050, R01HL151283, R01HL148565, R01HL135242, and R01HL151152","R01 HL172803","HHSN268201800015I","Harold M. English Fellowship Fund","R01 HL148565","R01 HL105756","HHSN268201600018C","U01 HL130114","N01 HC085083","KAW 2020.0239","N01 HC085082","N01 HC085081","5U01DK108809","1R01 HL159081, R01 HL153499","K99HL165024","N01 HC085086","TNE-18CVD04","UL1 TR001881","R00HG012956","N01 HC095166","N01 HC095165","N01 HC095168","N01 HC095167","HHSN268201800014C","N01 HC085080","N01 HC095169","R01 MH104964","N01 HC095160","R01 HL159081","N01 HC095162","R01HL148565","N01 HC095161","HHSN268201800014I","N01 HC095164","N01 HC095163","DP5 OD029586","24RGRSG1275749, 25SFRNCCKMS1443062, 25SFRNPCKMS1463898","K08 HL161445","U01 DK108809","UL1 TR000040","R01 HL153499","K99 HL165024","75N92021D00006","R01 DK125782","HHSN268201800001C","R01HL173028, R01HL148565","HHSN268201800013I","Paul and Phyllis Fireman Endowed Chair in Vascular Medicine","75N92020D00007","HHSN268201800012C","HHSN268201800012I","HHSN268201200036C","75N92020D00001","75N92020D00002","HHSN268201600001C","75N92020D00005","R01 HL142711","75N92020D00006","75N92020D00003","75N92020D00004","HHSN268201500003C","R01 HL127564","UL1 TR001079","R01 HL134892","N01 HC095159","HHSN268201800011C","HHSN268201800011I","R01 HL173028","HHSN268201600002C","N01 HC085079","HHSN268201500003I"],"pubmed_authors":["Psaty BM","Gerszten RE","Rotter JI","Griffin G","Ebert BL","Rich SS","Wilson JG","Honigberg MC","Lin AE","Peloso GM","Manson JE","Vasan RS","Sankaran VG","Vellarikkal SK","Schuermans A","NHLBI Trans-Omics for Precision Medicine","Li L","Libby P","Gupta RM","Lange LA","Niroula A","Katz DH","Haring B","Dron JS","Ganz P","Vromman A","Ballantyne CM","Correa A","Haidermota S","Gibson CJ","Ganesh S","Antoine T","Uddin MM","Post WS","Tahir UA","Yu Z","Hornsby W","Natarajan P","Min YI","Weinstock J","Reiner AP","Austin TR","Nakao T","Rentz T","Nguyen NQH","Bis JC","Coresh J","Yu B","Jaiswal S","Kooperberg C","Fang S","Bick AG","Pan M"],"additional_accession":[]},"is_claimable":false,"name":"Human plasma proteomic profile of clonal hematopoiesis.","description":"Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations show substantial heterogeneity by driver genes, sex, and race, and were enriched for immun","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T09:05:31.196Z","creation":"2026-05-28T03:12:07.702Z"},"accession":"S-EPMC12748892","cross_references":{"pubmed":["41309676"],"doi":["10.1038/s41467-025-66755-z"]}}