{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(6)"],"submitter":["Lin F"],"pubmed_abstract":["<h4>Objectives</h4>To investigate the molecular mechanism by which He's Yangchao recipe improves ovarian function in premature ovarian insufficiency (POI) mice through intestinal flora modulation.<h4>Methods</h4>Forty female ICR mice (aged 6-8 weeks) were intraperitoneally injected with cyclophosphamide (150 mg/kg) to establish a POI model, while 10 untreated mice served as the blank control. The cyclophosphamide-injected mice were randomly divided into four groups with 10 mice in each group: low-dose He's Yangchao recipe (crude herb, 6 g/kg), high-dose He's Yangchao recipe (crude herb, 25 g/kg), estradiol (positive control), and model control (distilled water). Treatments were administered daily by gavage for 6 weeks. Vaginal exfoliated cells were stained with Wright-Giemsa solution to mo"],"journal":["Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences"],"pagination":["785-793"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12750045"],"repository":["biostudies-literature"],"pubmed_title":["[He&lt;b&gt;'&lt;/b&gt;s Yangchao recipe ameliorates premature ovarian insuf-ficiency by remodeling intestinal microbiota to promote granulosa cell glycolysis]."],"pmcid":["PMC12750045"],"pubmed_authors":["Wang R","Lin F","Miao C","Liu Q","Chen Y","Zhao Y","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"[He&lt;b&gt;'&lt;/b&gt;s Yangchao recipe ameliorates premature ovarian insuf-ficiency by remodeling intestinal microbiota to promote granulosa cell glycolysis].","description":"<h4>Objectives</h4>To investigate the molecular mechanism by which He's Yangchao recipe improves ovarian function in premature ovarian insufficiency (POI) mice through intestinal flora modulation.<h4>Methods</h4>Forty female ICR mice (aged 6-8 weeks) were intraperitoneally injected with cyclophosphamide (150 mg/kg) to establish a POI model, while 10 untreated mice served as the blank control. The cyclophosphamide-injected mice were randomly divided into four groups with 10 mice in each group: low-dose He's Yangchao recipe (crude herb, 6 g/kg), high-dose He's Yangchao recipe (crude herb, 25 g/kg), estradiol (positive control), and model control (distilled water). Treatments were administered daily by gavage for 6 weeks. Vaginal exfoliated cells were stained with Wright-Giemsa solution to mo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-28T03:22:37.537Z","creation":"2026-05-28T03:12:02.107Z"},"accession":"S-EPMC12750045","cross_references":{"pubmed":["40660868"],"doi":["10.3724/zdxbyxb-2024-0604"]}}