biostudies-literatureMcMenamin KJHorizon TherapeuticsRRD VARehabilitation Research and Development ServiceU.S. Department of DefenseNational Institutes of HealthClinical Science Research and DevelopmentU.S. Department of Veterans AffairsNational Institute of General Medical SciencesNIH HHSNIGMS NIH HHSCSRD VA1409-1417https://www.ebi.ac.uk/biostudies/studies/S-EPMC12750132biostudies-literatureUnknown77(12)<h4>Objective</h4>Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA).<h4>Methods</h4>Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training data set) and the Veterans Affairs Rheumatoid Arthritis Registry (VARA; validation data set). Multivariable linear regression was used to estimate the relationship between cross-sectional pain scores and 36 fibromyalgia (FM)-associated SNPs in FORWARD. SNP alleles were summed and weighted by these regression coefficients to generate a genetic risk score (GRS) for pain for each participant in both cohorts. Linear reArthritis care & researchDevelopment and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.PMC12750132I01 RX0036445T32GM075766‐17IK2 CX002351CX0023515T32GM075766-17T32 GM075766I01 CX001703U54GM115458PR200793U54 GM115458IK2 CX002203McMenamin KJMichaud KWheeler ABaker JFEngland BRMikuls TRMarch MWysham KDXiao RToikumo SRiley TRKember RLWipfler KKranzler HRSauer BCannon GWfalseDevelopment and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.<h4>Objective</h4>Several single-nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA).<h4>Methods</h4>Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic Diseases, training data set) and the Veterans Affairs Rheumatoid Arthritis Registry (VARA; validation data set). Multivariable linear regression was used to estimate the relationship between cross-sectional pain scores and 36 fibromyalgia (FM)-associated SNPs in FORWARD. SNP alleles were summed and weighted by these regression coefficients to generate a genetic risk score (GRS) for pain for each participant in both cohorts. Linear re2025-01-01T00:00:00Z2025 Dec2026-06-06T10:39:36.224Z2026-05-29T03:12:31.176ZS-EPMC127501324058360610.1002/acr.25588