{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bungei J"],"funding":["FIC NIH HHS","NIAID NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751502"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Malaria treatment interventions play a central role in the prevention and control of Plasmodium falciparum infections worldwide. However, the emergence and spread of resistant P. falciparum parasites pose a serious public health challenge, as they reduce the effectiveness of antimalarial drugs and contribute to an increased global malaria burden. This study conducted a comparative molecular surveillance of antimalarial drug resistance in P. falciparum isolates from the Lake endemic and highland epidemic-prone regions of western Kenya.<h4>Methods</h4>A cross-sectional study design was employed to screen patients presenting with malaria-associated symptoms among residents of the lake-endemic region of Nyando sub-County in Kisumu County and the highland epidemic-prone regio"],"journal":["Malaria journal"],"pubmed_title":["Comparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya."],"pmcid":["PMC12751502"],"funding_grant_id":["D43 TW001505","U19 AI129326","U19AI129326 and D43TW001505"],"pubmed_authors":["Lee MC","Zhong D","Wang C","Zhou G","Atieli H","Githure J","Bungei J","Oyweri J","Yan G","Ouma C"],"additional_accession":[]},"is_claimable":false,"name":"Comparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya.","description":"<h4>Background</h4>Malaria treatment interventions play a central role in the prevention and control of Plasmodium falciparum infections worldwide. However, the emergence and spread of resistant P. falciparum parasites pose a serious public health challenge, as they reduce the effectiveness of antimalarial drugs and contribute to an increased global malaria burden. This study conducted a comparative molecular surveillance of antimalarial drug resistance in P. falciparum isolates from the Lake endemic and highland epidemic-prone regions of western Kenya.<h4>Methods</h4>A cross-sectional study design was employed to screen patients presenting with malaria-associated symptoms among residents of the lake-endemic region of Nyando sub-County in Kisumu County and the highland epidemic-prone regio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T09:01:00.248Z","creation":"2026-05-28T03:11:15.176Z"},"accession":"S-EPMC12751502","cross_references":{"pubmed":["41420179"],"doi":["10.1186/s12936-025-05755-2"]}}