biostudies-literatureBungei JFIC NIH HHSNIAID NIH HHSNational Institutes of HealthNIH HHS453https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751502biostudies-literatureUnknown24(1)<h4>Background</h4>Malaria treatment interventions play a central role in the prevention and control of Plasmodium falciparum infections worldwide. However, the emergence and spread of resistant P. falciparum parasites pose a serious public health challenge, as they reduce the effectiveness of antimalarial drugs and contribute to an increased global malaria burden. This study conducted a comparative molecular surveillance of antimalarial drug resistance in P. falciparum isolates from the Lake endemic and highland epidemic-prone regions of western Kenya.<h4>Methods</h4>A cross-sectional study design was employed to screen patients presenting with malaria-associated symptoms among residents of the lake-endemic region of Nyando sub-County in Kisumu County and the highland epidemic-prone regioMalaria journalComparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya.PMC12751502D43 TW001505U19 AI129326U19AI129326 and D43TW001505Lee MCZhong DWang CZhou GAtieli HGithure JBungei JOyweri JYan GOuma CfalseComparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya.<h4>Background</h4>Malaria treatment interventions play a central role in the prevention and control of Plasmodium falciparum infections worldwide. However, the emergence and spread of resistant P. falciparum parasites pose a serious public health challenge, as they reduce the effectiveness of antimalarial drugs and contribute to an increased global malaria burden. This study conducted a comparative molecular surveillance of antimalarial drug resistance in P. falciparum isolates from the Lake endemic and highland epidemic-prone regions of western Kenya.<h4>Methods</h4>A cross-sectional study design was employed to screen patients presenting with malaria-associated symptoms among residents of the lake-endemic region of Nyando sub-County in Kisumu County and the highland epidemic-prone regio2025-01-01T00:00:00Z2025 Dec2026-06-06T09:01:00.248Z2026-05-28T03:11:15.176ZS-EPMC127515024142017910.1186/s12936-025-05755-2