{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie F"],"funding":["Beijing Chao-yang Hospital Golden Seeds Fundation","Beijing Nature Science Foundation"],"pagination":["803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751610"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently used in clinical practice still have critical limitations, including low penetration efficiency of antimicrobial agents, poor anti-inflammatory effects, and a lack of effective strategies to promote functional dentin regeneration. These factors restrict the therapeutic efficacy of pulp vitality preservation treatments. In this study, by constructing a composite of Metal-Organic Framework (MOF@Cr-Al) and methacrylated gelatin (GelMA), we have developed a photo-curable multifunctional hydrogel (GelMA-MOF@Cr-Al) with potential for clinical translation. The "],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions."],"pmcid":["PMC12751610"],"funding_grant_id":["CYJZ202436","7222222"],"pubmed_authors":["Xie F","Diao Z","Qin M","Wang Y","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.","description":"Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently used in clinical practice still have critical limitations, including low penetration efficiency of antimicrobial agents, poor anti-inflammatory effects, and a lack of effective strategies to promote functional dentin regeneration. These factors restrict the therapeutic efficacy of pulp vitality preservation treatments. In this study, by constructing a composite of Metal-Organic Framework (MOF@Cr-Al) and methacrylated gelatin (GelMA), we have developed a photo-curable multifunctional hydrogel (GelMA-MOF@Cr-Al) with potential for clinical translation. The ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T08:23:44.13Z","creation":"2026-05-27T03:11:54.314Z"},"accession":"S-EPMC12751610","cross_references":{"pubmed":["41310664"],"doi":["10.1186/s12951-025-03823-y"]}}