biostudies-literatureXie FBeijing Chao-yang Hospital Golden Seeds FundationBeijing Nature Science Foundation803https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751610biostudies-literatureUnknown23(1)Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently used in clinical practice still have critical limitations, including low penetration efficiency of antimicrobial agents, poor anti-inflammatory effects, and a lack of effective strategies to promote functional dentin regeneration. These factors restrict the therapeutic efficacy of pulp vitality preservation treatments. In this study, by constructing a composite of Metal-Organic Framework (MOF@Cr-Al) and methacrylated gelatin (GelMA), we have developed a photo-curable multifunctional hydrogel (GelMA-MOF@Cr-Al) with potential for clinical translation. The Journal of nanobiotechnologyPhotocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.PMC12751610CYJZ2024367222222Xie FDiao ZQin MWang YZhu CfalsePhotocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently used in clinical practice still have critical limitations, including low penetration efficiency of antimicrobial agents, poor anti-inflammatory effects, and a lack of effective strategies to promote functional dentin regeneration. These factors restrict the therapeutic efficacy of pulp vitality preservation treatments. In this study, by constructing a composite of Metal-Organic Framework (MOF@Cr-Al) and methacrylated gelatin (GelMA), we have developed a photo-curable multifunctional hydrogel (GelMA-MOF@Cr-Al) with potential for clinical translation. The 2025-01-01T00:00:00Z2025 Nov2026-06-06T08:23:44.13Z2026-05-27T03:11:54.314ZS-EPMC127516104131066410.1186/s12951-025-03823-y