{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rojas-Castro M"],"funding":["European Centre for Disease Prevention and Control"],"pagination":["697"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Healthcare workers (HCWs) face high occupational exposure to SARS-CoV-2 and are a priority group for vaccination. Both natural infection and vaccination-individually or combined as hybrid immunity-confer protection against SARS-CoV-2 infection. This study aimed to evaluate the protection conferred by hybrid, infection-induced, and booster vaccine-induced immunity against laboratory-confirmed SARS-CoV-2 infections in HCWs during the circulation of three pandemic and one post-pandemic Omicron sublineages.<h4>Methods</h4>We conducted a prospective cohort study of HCWs from 18 hospitals across nine European countries. Participants underwent RT-PCR testing at enrolment and during weekly or fortnightly follow-ups. The study period was divided based on dominant Omicron sublinea"],"journal":["BMC medicine"],"pubmed_title":["Hybrid, infection- and vaccination-induced protection against laboratory- confirmed SARS-CoV-2 infection in a European multi-centre prospective cohort of healthcare workers, 2021-2024."],"pmcid":["PMC12751633"],"funding_grant_id":["ECDC/2021/017"],"pubmed_authors":["Gimenez CM","Dias D","Henriques CV","Rasic B","Snipe HD","Santos JA","Alves J","Ferguson L","Barzdina EA","Baro AIT","Mulchandani R","Lanca M","Garcia-Garcia JJ","Lamonica S","Moran C","Zelli S","Jollard SD","Curkovic M","Sarajlic G","Murri R","Zvirbulis V","Szuldrzynski K","Clusa L","O'Donell J","Menchinelli G","Guiomar R","Repovecki S","Hrisca RM","Spolti A","Popescu CP","Codreanu DR","Nardone A","McGrath J","Zavadska D","Cameo NFM","Abolina I","Gomes L","Falasca B","Domegan L","Florescu SA","Gravele D","Lopez C","Craiu M","Sui J","Marco NT","Rojas-Castro M","Santangelo R","Pozo F","Budimir A","Gaio V","Kosa AG","Amaral AP","Kenny C","Makaric P","Cavlek TV","Recine C","Petir K","Vicente TV","Larrea DO","Tabain I","Marin A","Uuskula A","Bacci S","Grataloup YG","Latorre-Millan M","Makaric ZL","Savulescu C","Carbo CC","Andres MGM","Lohur L","Petrovic G","Mateos DM","De Gaetano Donati K","Blasco AMS","Bergin C","Moriarty A","Bosnjak Z","Angos BG","De Angelis G","VEBIS HCW VE study group","Ascaso IE","Fleming C","Machado A","Melo A","Ganser I","Kernan M","Del Moral Redolat B","Zarko T","Jordan I","Bonfanti P","Prats A","Perez-Arguello A","Miron VD","Lazar M","Alejaldre MPA","Carvalho H","Subirats P","Meisters J","Ergle E","Cisneros M","Munoz-Almagro C","Pohrib SM","Milagro AM","Zemite L","Krievins D","Brolin K","Sepp H","Lopez AR"],"additional_accession":[]},"is_claimable":false,"name":"Hybrid, infection- and vaccination-induced protection against laboratory- confirmed SARS-CoV-2 infection in a European multi-centre prospective cohort of healthcare workers, 2021-2024.","description":"<h4>Background</h4>Healthcare workers (HCWs) face high occupational exposure to SARS-CoV-2 and are a priority group for vaccination. Both natural infection and vaccination-individually or combined as hybrid immunity-confer protection against SARS-CoV-2 infection. This study aimed to evaluate the protection conferred by hybrid, infection-induced, and booster vaccine-induced immunity against laboratory-confirmed SARS-CoV-2 infections in HCWs during the circulation of three pandemic and one post-pandemic Omicron sublineages.<h4>Methods</h4>We conducted a prospective cohort study of HCWs from 18 hospitals across nine European countries. Participants underwent RT-PCR testing at enrolment and during weekly or fortnightly follow-ups. The study period was divided based on dominant Omicron sublinea","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T08:25:42.816Z","creation":"2026-05-27T03:12:09.837Z"},"accession":"S-EPMC12751633","cross_references":{"pubmed":["41466249"],"doi":["10.1186/s12916-025-04503-2"]}}