biostudies-literatureDe Oliveira TLRFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro810https://www.ebi.ac.uk/biostudies/studies/S-EPMC12751815biostudies-literatureUnknown25(1)<h4>Background</h4>The COVID-19 pandemic has dramatically impacted in patients from Intensive Care Units (ICUs), making them more vulnerable to infection/colonization by clinically relevant pathogens. However, little is known about the Staphylococcus aureus isolates that colonized these patients during the pandemic.<h4>Methods</h4>Consecutive S. aureus isolates from surveillance swabs of patients of two ICUs of a hospital in Rio de Janeiro, between September 2020 and September 2021, were evaluated for phenotypic antimicrobial resistance. Methicillin-resistant S. aureus (MRSA) isolates were evaluated for resistance and virulence genes, biofilm production, and their genotypic profiles. Medical records were accessed for clinical and demographic data.<h4>Results</h4>Among 255 patients colonizeBMC microbiologyHigh colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.PMC12751815#E-26/203.296/2017; #E-26/200.419/2023, #E-26/010.000172/2016, #E-26/010.001463/2019, #E-26/010.101056/2018; #E-26/211.554/2019 (Projeto REDES); #E-26/201.071/2020; #E-26/211.284/2021; #E-26/201.454/2021 and #E-26/205.939/2022Cavalcante FSda Costa de Souza CRDe Oliveira TLRCarvalho Avila VInfection Control Group HUCFF/UFRJde Sant'Ana ACDos Santos KRNMacharete TCGuedes EMIgari GFPantoja Freire JNouer SAFerreira ALPCastineiras ACGuimaraes LFAGonzalez CMfalseHigh colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.<h4>Background</h4>The COVID-19 pandemic has dramatically impacted in patients from Intensive Care Units (ICUs), making them more vulnerable to infection/colonization by clinically relevant pathogens. However, little is known about the Staphylococcus aureus isolates that colonized these patients during the pandemic.<h4>Methods</h4>Consecutive S. aureus isolates from surveillance swabs of patients of two ICUs of a hospital in Rio de Janeiro, between September 2020 and September 2021, were evaluated for phenotypic antimicrobial resistance. Methicillin-resistant S. aureus (MRSA) isolates were evaluated for resistance and virulence genes, biofilm production, and their genotypic profiles. Medical records were accessed for clinical and demographic data.<h4>Results</h4>Among 255 patients colonize2025-01-01T00:00:00Z2025 Nov2026-06-06T07:42:24.301Z2026-05-27T03:11:47.798ZS-EPMC127518154129925310.1186/s12866-025-04526-y