biostudies-literatureShen DSTI 2030-Major Projects1167https://www.ebi.ac.uk/biostudies/studies/S-EPMC12752173biostudies-literatureUnknown25(1)<h4>Background</h4>Methamphetamine (METH)-induced psychosis (MAP), characterized by transient schizophreniform symptoms, affects approximately 43% of individuals with methamphetamine use disorders (MUD). However, the cortical atrophy pattern associated with MAP remain unclear.<h4>Methods</h4>Ninety-four male patients with MUD (62 without psychotic symptoms [MA] and 32 MAP) and 61 healthy controls (HCs) underwent high-resolution T1-weighted MRI and clinical assessments. Surface-based morphological (SBM) analysis using FreeSurfer 7.1.1 was conducted to explore cortical thickness and volume difference among groups. We also examined the correlation between brain structural changes and clinical variables.<h4>Results</h4>The MAP group showed significant cortical thinning in the left superior temBMC psychiatryCortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study.PMC127521732021ZD0202105Li JTao HShen DLai MXu JLuo DfalseCortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study.<h4>Background</h4>Methamphetamine (METH)-induced psychosis (MAP), characterized by transient schizophreniform symptoms, affects approximately 43% of individuals with methamphetamine use disorders (MUD). However, the cortical atrophy pattern associated with MAP remain unclear.<h4>Methods</h4>Ninety-four male patients with MUD (62 without psychotic symptoms [MA] and 32 MAP) and 61 healthy controls (HCs) underwent high-resolution T1-weighted MRI and clinical assessments. Surface-based morphological (SBM) analysis using FreeSurfer 7.1.1 was conducted to explore cortical thickness and volume difference among groups. We also examined the correlation between brain structural changes and clinical variables.<h4>Results</h4>The MAP group showed significant cortical thinning in the left superior tem2025-01-01T00:00:00Z2025 Nov2026-06-06T08:35:16.317Z2026-05-27T03:12:35.866ZS-EPMC127521734125761610.1186/s12888-025-07603-8