{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeong JH"],"funding":["National Research Foundation of Korea"],"pagination":["169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12752189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Cancer is a leading cause of mortality worldwide, necessitating the development of novel therapeutic targets and strategies to prevent recurrence and metastasis. In this study, we aimed to evaluate whether a recombinant attenuated Salmonella vaccine (RASV) can stimulate antitumor immunity and prevent cancer progression in vivo.<h4>Methods</h4>We established a mouse model by transplanting cancer cells subcutaneously 4 weeks after oral RASV inoculation and analyzed bone marrow (BM) cells and tumor-infiltrated immune cells by flow cytometry. Further, we established a 4 T-1-induced metastatic cancer model to evaluate the RASV-mediated prevention of tumor metastasis.<h4>Results</h4>Adjuvant RASV significantly reduced tumor growth by enhancing CD8<sup>+</sup> T cell activity a"],"journal":["Cell & bioscience"],"pubmed_title":["Recombinant attenuated Salmonella vaccine promotes CD8&lt;sup&gt;+&lt;/sup&gt; T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7."],"pmcid":["PMC12752189"],"funding_grant_id":["2020R1A5A8019180","RS-2023-00208385"],"pubmed_authors":["Ahn JH","Kim DH","Jeong JH","Kim DJ","Park JH","Choi SS","Han Y","Tae N","Kweon MN","Ko HJ","Kim CW","Jang AR","Cho J"],"additional_accession":[]},"is_claimable":false,"name":"Recombinant attenuated Salmonella vaccine promotes CD8&lt;sup&gt;+&lt;/sup&gt; T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7.","description":"<h4>Background</h4>Cancer is a leading cause of mortality worldwide, necessitating the development of novel therapeutic targets and strategies to prevent recurrence and metastasis. In this study, we aimed to evaluate whether a recombinant attenuated Salmonella vaccine (RASV) can stimulate antitumor immunity and prevent cancer progression in vivo.<h4>Methods</h4>We established a mouse model by transplanting cancer cells subcutaneously 4 weeks after oral RASV inoculation and analyzed bone marrow (BM) cells and tumor-infiltrated immune cells by flow cytometry. Further, we established a 4 T-1-induced metastatic cancer model to evaluate the RASV-mediated prevention of tumor metastasis.<h4>Results</h4>Adjuvant RASV significantly reduced tumor growth by enhancing CD8<sup>+</sup> T cell activity a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T07:48:23.378Z","creation":"2026-05-27T03:12:00.558Z"},"accession":"S-EPMC12752189","cross_references":{"pubmed":["41462488"],"doi":["10.1186/s13578-025-01510-x"]}}