biostudies-literatureUnknown16Fleegal AL<i>Myxococcus xanthus</i> is a ubiquitous, obligately aerobic soil bacterium. <i>M. xanthus</i> has many two-component systems that serve to regulate responses to environmental stimuli. One of these systems, the multicomponent signaling system named the NmpRSTU pathway has been demonstrated to regulate genes that are predicted to be important for oxygen utilization, including the gene <i>mxan_5531,</i> which encodes a predicted hemerythrin-like protein. The family of proteins that includes hemerythrin-like proteins binds oxygen coordinated by a di-iron cofactor. Based on the sequence alignments and predictive structural analysis, we have determined that <i>M. xanthus</i> encodes at least five other predicted hemerythrin-like proteins. Of these six proteins predicted to be hemerythrin-like Frontiers in microbiology1734440https://www.ebi.ac.uk/biostudies/studies/S-EPMC12753109biostudies-literatureExpression of hemerythrin-like genes from the obligate aerobe &lt;i&gt;Myxococcus xanthus&lt;/i&gt; improves the growth of the industrially relevant &lt;i&gt;Gluconobacter oxydans&lt;/i&gt;.PMC12753109Stenzel MJSchweiger PFleegal ALBretl DJfalseExpression of hemerythrin-like genes from the obligate aerobe &lt;i&gt;Myxococcus xanthus&lt;/i&gt; improves the growth of the industrially relevant &lt;i&gt;Gluconobacter oxydans&lt;/i&gt;.<i>Myxococcus xanthus</i> is a ubiquitous, obligately aerobic soil bacterium. <i>M. xanthus</i> has many two-component systems that serve to regulate responses to environmental stimuli. One of these systems, the multicomponent signaling system named the NmpRSTU pathway has been demonstrated to regulate genes that are predicted to be important for oxygen utilization, including the gene <i>mxan_5531,</i> which encodes a predicted hemerythrin-like protein. The family of proteins that includes hemerythrin-like proteins binds oxygen coordinated by a di-iron cofactor. Based on the sequence alignments and predictive structural analysis, we have determined that <i>M. xanthus</i> encodes at least five other predicted hemerythrin-like proteins. Of these six proteins predicted to be hemerythrin-like 2025-01-01T00:00:00Z20252026-05-28T03:23:47.181Z2026-05-28T03:12:12.138ZS-EPMC127531094147720610.3389/fmicb.2025.1734440