{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["He R"],"pubmed_abstract":["Purpose
Preclinical studies have demonstrated that FLASH radiation therapy (RT) delivered at ultrahigh-dose rates exerts a preferential normal tissue-sparing effect. This study aimed to delineate the disparities in delayed cognitive function and biological outcomes of whole-brain irradiation in healthy mice, comparing FLASH-RT with conventional RT (CONV-RT).Methods and materials
Eighty adult male C57BL/6J mice were divided into 5 groups: Sham, CONV-RT10Gy, CONV-RT20Gy, FLASH-RT10Gy, and FLASH-RT20Gy. Whole-brain irradiation was conducted on mice using a miniaturized x-ray FLASH platform at field-average dose rates of 2 Gy/min for CONV-RT and 213 Gy/s for FLASH-RT. Two months after irradiation, we assessed the mice's cognitive function and the number of astrocytes and neuron"],"journal":["Advances in radiation oncology"],"pagination":["101950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12754397"],"repository":["biostudies-literature"],"pubmed_title":["The Impacts of FLASH Radiation Therapy and Conventional Radiation Therapy on the Cognitive Abilities of Mice."],"pmcid":["PMC12754397"],"pubmed_authors":["Li W","Liu X","Qu B","Yang Y","Zhang J","Wu D","Cheng G","He R","Du L","Wang J","Xie S"],"additional_accession":[]},"is_claimable":false,"name":"The Impacts of FLASH Radiation Therapy and Conventional Radiation Therapy on the Cognitive Abilities of Mice.","description":"Purpose
Preclinical studies have demonstrated that FLASH radiation therapy (RT) delivered at ultrahigh-dose rates exerts a preferential normal tissue-sparing effect. This study aimed to delineate the disparities in delayed cognitive function and biological outcomes of whole-brain irradiation in healthy mice, comparing FLASH-RT with conventional RT (CONV-RT).Methods and materials
Eighty adult male C57BL/6J mice were divided into 5 groups: Sham, CONV-RT10Gy, CONV-RT20Gy, FLASH-RT10Gy, and FLASH-RT20Gy. Whole-brain irradiation was conducted on mice using a miniaturized x-ray FLASH platform at field-average dose rates of 2 Gy/min for CONV-RT and 213 Gy/s for FLASH-RT. Two months after irradiation, we assessed the mice's cognitive function and the number of astrocytes and neuron","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T09:24:09.956Z","creation":"2026-05-28T03:11:34.554Z"},"accession":"S-EPMC12754397","cross_references":{"pubmed":["41479882"],"doi":["10.1016/j.adro.2025.101950"]}}