{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu D"],"funding":["Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province"],"pagination":["1433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12754891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>A sustained oversupply of monocytes and markedly decreased levels of high-density lipoprotein cholesterol (HDL-C) are notable in high-risk groups with residual cardiovascular risk, despite aggressive low-density lipoprotein cholesterol (LDL-C) lowering. This study aimed to explore whether an imbalance in circulating monocyte and HDL-C levels accounts for the residual risk of incident myocardial infarction (MI) within optimal LDL-C levels.<h4>Methods</h4>A total of 48,522 participants free of cardiovascular diseases from a real-life, prospective cohort (Kailuan study) were included. The monocyte count, HDL-C level and monocyte-to-HDL-C ratio (MHR), calculated as time-averaged cumulative and baseline values, were used as the exposures. Time-to-event survival analyses were "],"journal":["Journal of translational medicine"],"pubmed_title":["Imbalances in circulating monocyte and high-density lipoprotein cholesterol exacerbates the residual risk of incident myocardial infarction beyond LDL-C: a real-life, prospective cohort study."],"pmcid":["PMC12754891"],"funding_grant_id":["202053-75","202053-74","STKJ2023003"],"pubmed_authors":["Li X","Ding X","Wu S","Wang W","Chen Y","Wu D","Balmer L","Lan Y"],"additional_accession":[]},"is_claimable":false,"name":"Imbalances in circulating monocyte and high-density lipoprotein cholesterol exacerbates the residual risk of incident myocardial infarction beyond LDL-C: a real-life, prospective cohort study.","description":"<h4>Background</h4>A sustained oversupply of monocytes and markedly decreased levels of high-density lipoprotein cholesterol (HDL-C) are notable in high-risk groups with residual cardiovascular risk, despite aggressive low-density lipoprotein cholesterol (LDL-C) lowering. This study aimed to explore whether an imbalance in circulating monocyte and HDL-C levels accounts for the residual risk of incident myocardial infarction (MI) within optimal LDL-C levels.<h4>Methods</h4>A total of 48,522 participants free of cardiovascular diseases from a real-life, prospective cohort (Kailuan study) were included. The monocyte count, HDL-C level and monocyte-to-HDL-C ratio (MHR), calculated as time-averaged cumulative and baseline values, were used as the exposures. Time-to-event survival analyses were ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T15:35:37.535Z","creation":"2026-07-06T03:10:43.106Z"},"accession":"S-EPMC12754891","cross_references":{"pubmed":["41469713"],"doi":["10.1186/s12967-025-07028-7"]}}