biostudies-literatureUnknown16Shitaye GLong COVID, or post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), refers to a range of persistent health effects associated with SARS-CoV-2 infection. Long COVID is a complex, multisystem disorder that can affect nearly every organ system and is strongly linked with the incidence of diabetes and other chronic conditions. Increasing evidence also connects persistent SARS-CoV-2 infection with the development of new-onset diabetes and other metabolic disorders. In this review, we assess the current evidence and discuss the incidence of new-onset diabetes, along with the pathobiological mechanisms by which SARS-CoV-2 may contribute to the progression of both new-onset type 1 and type 2 diabetes mellitus (T1DM and T2DM). We summarize the latestFrontiers in endocrinology1737894https://www.ebi.ac.uk/biostudies/studies/S-EPMC12756089biostudies-literatureMolecular analysis of long COVID and new-onset diabetes mellitus: pathobiological relationships and current mechanistic views.PMC12756089D'Abrosca GFattorusso RMekonnen ZIsernia CGetie MAmuamuta AShitaye GMalgieri GfalseMolecular analysis of long COVID and new-onset diabetes mellitus: pathobiological relationships and current mechanistic views.Long COVID, or post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), refers to a range of persistent health effects associated with SARS-CoV-2 infection. Long COVID is a complex, multisystem disorder that can affect nearly every organ system and is strongly linked with the incidence of diabetes and other chronic conditions. Increasing evidence also connects persistent SARS-CoV-2 infection with the development of new-onset diabetes and other metabolic disorders. In this review, we assess the current evidence and discuss the incidence of new-onset diabetes, along with the pathobiological mechanisms by which SARS-CoV-2 may contribute to the progression of both new-onset type 1 and type 2 diabetes mellitus (T1DM and T2DM). We summarize the latest2025-01-01T00:00:00Z20252026-06-06T11:15:11.699Z2026-05-29T03:12:28.887ZS-EPMC127560894148814810.3389/fendo.2025.1737894