{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sokoloski KJ"],"funding":["National Institute of Allergy and Infectious Diseases","startup package from the University of Louisville","NIAID NIH HHS","Integrated Programs in Biomedical Sciences","Jewish Heritage Fund for Excellence","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2609389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12758272"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Sindbis virus (SINV), a widely distributed alphavirus, is both a foundational model for viral replication studies and an underrecognized human pathogen. Despite its typically mild presentation, SINV can lead to prolonged joint pain and, in rare cases, neurological complications. This review explores SINV's molecular biology and clinical manifestations, particularly its role in causing Sindbis Fever - a self-limiting but potentially chronic arthritic disease. Molecular insights reveal mechanisms of immune evasion, neurovirulence, and persistent infection, highlighting SINV's potential for broader public health impact, especially under changing climatic conditions. This review also identifies key virulence determinants and discusses the virus's utility as a model for studying alphaviral ence"],"journal":["Virulence"],"pubmed_title":["The pathogenicity and virulence of Sindbis virus."],"pmcid":["PMC12758272"],"funding_grant_id":["P20 GM125504","R01 AI185075","R01 AI153275"],"pubmed_authors":["Isom CM","Moni S","Sokoloski KJ","Karki D"],"additional_accession":[]},"is_claimable":false,"name":"The pathogenicity and virulence of Sindbis virus.","description":"Sindbis virus (SINV), a widely distributed alphavirus, is both a foundational model for viral replication studies and an underrecognized human pathogen. Despite its typically mild presentation, SINV can lead to prolonged joint pain and, in rare cases, neurological complications. This review explores SINV's molecular biology and clinical manifestations, particularly its role in causing Sindbis Fever - a self-limiting but potentially chronic arthritic disease. Molecular insights reveal mechanisms of immune evasion, neurovirulence, and persistent infection, highlighting SINV's potential for broader public health impact, especially under changing climatic conditions. This review also identifies key virulence determinants and discusses the virus's utility as a model for studying alphaviral ence","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Dec","modification":"2026-06-06T09:15:13.525Z","creation":"2026-05-28T03:12:21.701Z"},"accession":"S-EPMC12758272","cross_references":{"pubmed":["41442410"],"doi":["10.1080/21505594.2025.2609389"]}}