{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Heerspink HJL"],"funding":["NIDDK NIH HHS"],"pagination":["32-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12758604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["179(1)"],"pubmed_abstract":["<h4>Background</h4>Urinary albumin-creatinine ratio (UACR) and urinary protein-creatinine ratio (UPCR) are both used in clinical practice to diagnose and monitor chronic kidney disease (CKD). Which measure exhibits stronger associations with clinical outcomes and whether this varies by patient characteristics are unknown.<h4>Objective</h4>To assess and compare the performance of UACR and UPCR across CKD-related clinical outcomes.<h4>Design</h4>Individual patient-level meta-analysis.<h4>Setting</h4>38 research and clinical cohorts.<h4>Participants</h4>148 994 participants with same-day measurements of UACR and UPCR.<h4>Measurements</h4>We quantified the associations of UACR and UPCR with subsequent clinical outcomes, including kidney failure and cardiovascular events, using Cox proportional"],"journal":["Annals of internal medicine"],"pubmed_title":["Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis."],"pmcid":["PMC12758604"],"funding_grant_id":["R01 DK100446"],"pubmed_authors":["Bottinger EP","Ito Y","Fellstrom B","Sang Y","CKD Prognosis Consortium","Levey AS","Singh G","Sondheimer J","Alencar de Pinho N","Kabasawa K","Dember LM","Robinson-Cohen C","Polkinghorne K","Houillier P","Nitsch D","McArthur E","Garg AX","Tangri N","Shlipak MG","Chen J","He J","Naimark DMJ","Kirchner HL","Kornowske L","Ciemins E","Weir M","Sumida K","Mark PB","Carrero JJ","Ellis SB","Brunskill NJ","Shrestha P","Gansevoort RT","Heerspink HJL","Haymann JP","Akwo E","Mohl J","Major R","Sullivan MK","Chang AR","Flaherty C","Metzger M","Surapaneni A","Chadban S","Matsushita K","Jones C","Loos RJF","Tang M","Daratha K","Wang AY","Vernooij RWM","Djurdjev O","Shepherd D","Stengel B","Frimat L","Tanaka J","Combe C","Nadkarni GN","Levin A","Zafar W","Tuttle K","Grams ME","Ballew SH","Green J","Alicic R","Coresh J","Lees JS","Traynor JP","Medcalf J","Flamant M","Kovesdy CP","Narita I"],"additional_accession":[]},"is_claimable":false,"name":"Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis.","description":"<h4>Background</h4>Urinary albumin-creatinine ratio (UACR) and urinary protein-creatinine ratio (UPCR) are both used in clinical practice to diagnose and monitor chronic kidney disease (CKD). Which measure exhibits stronger associations with clinical outcomes and whether this varies by patient characteristics are unknown.<h4>Objective</h4>To assess and compare the performance of UACR and UPCR across CKD-related clinical outcomes.<h4>Design</h4>Individual patient-level meta-analysis.<h4>Setting</h4>38 research and clinical cohorts.<h4>Participants</h4>148 994 participants with same-day measurements of UACR and UPCR.<h4>Measurements</h4>We quantified the associations of UACR and UPCR with subsequent clinical outcomes, including kidney failure and cardiovascular events, using Cox proportional","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T18:07:41.553Z","creation":"2026-06-04T03:11:37.646Z"},"accession":"S-EPMC12758604","cross_references":{"pubmed":["41183334"],"doi":["10.7326/ANNALS-25-02117","10.7326/annals-25-02117"]}}