biostudies-literatureNamboodiripad AThe Bill and Melinda Gates Foundation, USA39-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC12759000biostudies-literatureUnknown92(Suppl 1)<h4>Objectives</h4>Intussusception (IS) is a condition in which proximal segment of the bowel invaginates into its distal segment. IS in young children can usually be managed using non-invasive methods, such as hydrostatic saline reduction (HSR), and surgery is generally reserved for cases in which non-invasive methods have failed. This study was conducted as part of a larger multicenter IS surveillance study. The objective of this analysis was to identify clinical and demographic factors associated with failed HSR in children hospitalized with IS.<h4>Methods</h4>In this observational study, children aged < 2 y hospitalized with IS confirmed according to the Brighton Collaboration criteria at a tertiary care center in Kerala were enrolled after obtaining parental informed consent. Children who underwent spontaneous reduction were excluded. Enrolled children were followed up until discharge.<h4>Results</h4>Of the 137 children who underwent HSR, 131 (95.6%) procedures were successful. HSR failed in six children (4.4%), and they required surgery; however, there were no deaths. The factors associated with failed HSR included low socioeconomic status [83% (5/6) vs. 32.1% (42/131); p = 0.042], a left-sided mass detected on ultrasonography [50% (3/6) vs. 6.9% (9/131); p = 0.004], and longer time from admission to the procedure (median: 5.5 vs. 3 h; p = 0.005).<h4>Conclusions</h4>This study demonstrates the importance of early HSR and exercising caution when a left-sided mass is detected on ultrasonography. With timely intervention, almost all cases can be successfully managed without surgery.Indian journal of pediatricsClinical Determinants of Unsuccessful Ultrasound-Guided Hydrostatic Saline Reduction in Children with Intussusception Post-Rotavirus Vaccine Introduction: Insights from a Tertiary Care Centre in Thrissur, Kerala, India.PMC12759000vide Investment ID INV-001196 to the Christian Medical College, VelloreChaudhary VSLingam RNamboodiripad AMachathi AKharat NThuruthiyath NAlappat MMXavier RGeorge GfalseClinical Determinants of Unsuccessful Ultrasound-Guided Hydrostatic Saline Reduction in Children with Intussusception Post-Rotavirus Vaccine Introduction: Insights from a Tertiary Care Centre in Thrissur, Kerala, India.<h4>Objectives</h4>Intussusception (IS) is a condition in which proximal segment of the bowel invaginates into its distal segment. IS in young children can usually be managed using non-invasive methods, such as hydrostatic saline reduction (HSR), and surgery is generally reserved for cases in which non-invasive methods have failed. This study was conducted as part of a larger multicenter IS surveillance study. The objective of this analysis was to identify clinical and demographic factors associated with failed HSR in children hospitalized with IS.<h4>Methods</h4>In this observational study, children aged < 2 y hospitalized with IS confirmed according to the Brighton Collaboration criteria at a tertiary care center in Kerala were enrolled after obtaining parental informed consent. Children who underwent spontaneous reduction were excluded. Enrolled children were followed up until discharge.<h4>Results</h4>Of the 137 children who underwent HSR, 131 (95.6%) procedures were successful. HSR failed in six children (4.4%), and they required surgery; however, there were no deaths. The factors associated with failed HSR included low socioeconomic status [83% (5/6) vs. 32.1% (42/131); p = 0.042], a left-sided mass detected on ultrasonography [50% (3/6) vs. 6.9% (9/131); p = 0.004], and longer time from admission to the procedure (median: 5.5 vs. 3 h; p = 0.005).<h4>Conclusions</h4>This study demonstrates the importance of early HSR and exercising caution when a left-sided mass is detected on ultrasonography. With timely intervention, almost all cases can be successfully managed without surgery.2025-01-01T00:00:00Z2025 Dec2026-05-28T03:22:52.361Z2026-05-28T03:12:05.762ZS-EPMC127590004118260010.1007/s12098-025-05778-2