{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Makhmut A"],"funding":["European Research Council","Deutschen Konsortium für Translationale Krebsforschung (DKTK)","Berliner Krebsgesellschaft Grant","Bundesministerium für Bildung und Forschung (BMBF)"],"pagination":["7-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12759074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["High-grade serous ovarian cancer (HGSOC) is often detected at an advanced stage, where curative treatment options are limited. Recent advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover molecular drivers of early tumorigenesis and novel therapeutic targets. Here, we present a comprehensive proteomic analysis of serous tubal intraepithelial carcinoma (STIC), the HGSOC precursor lesion, and concurrent invasive carcinoma, covering more than 10,000 proteins from ultra-low input archival tissue. STIC and HGSOC showed highly similar proteomes, clustering into two subtypes with distinct tumor-immune microenvironments and common remodeling of the extracellular matrix. We discovered cell-of-origin signatures from secretory fallopian tu"],"journal":["Molecular systems biology"],"pubmed_title":["Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets."],"pmcid":["PMC12759074"],"funding_grant_id":["DRFF202204","101115681","Young Investigator Grant 2022","161L0222"],"pubmed_authors":["Dragomir MP","Fritzsche S","Schmitt WD","Moebs M","Makhmut A","Taube ET","Coscia F"],"additional_accession":[]},"is_claimable":false,"name":"Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets.","description":"High-grade serous ovarian cancer (HGSOC) is often detected at an advanced stage, where curative treatment options are limited. Recent advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover molecular drivers of early tumorigenesis and novel therapeutic targets. Here, we present a comprehensive proteomic analysis of serous tubal intraepithelial carcinoma (STIC), the HGSOC precursor lesion, and concurrent invasive carcinoma, covering more than 10,000 proteins from ultra-low input archival tissue. STIC and HGSOC showed highly similar proteomes, clustering into two subtypes with distinct tumor-immune microenvironments and common remodeling of the extracellular matrix. We discovered cell-of-origin signatures from secretory fallopian tu","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T11:18:59.763Z","creation":"2026-07-04T03:11:32.781Z"},"accession":"S-EPMC12759074","cross_references":{"pubmed":["41233595"],"doi":["10.1038/s44320-025-00168-4"]}}