{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(1)"],"submitter":["Thye H"],"pubmed_abstract":["A catalyst screening for six different α-alkylation reactions of methyl sulfides with unsaturated substrates performed in hermetically sealable and inexpensive 42-well aluminum reactor blocks is described. As a result, a new titanium-catalyzed hydrothiomethylation reaction of alkenes, which takes place under C─H bond activation at the α-carbon atom of simple methyl sulfides, is presented. The best catalyst is prepared in situ from the readily available titanium catalyst precursor Ti(CH<sub>2</sub>SiMe<sub>3</sub>)<sub>4</sub>, a formamidinato ligand precursor, and the Lewis acid [Ph<sub>3</sub>C][B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>]. Although selected 1,2-disubstituted alkenes, for example, cyclohexene and cyclopentene, undergo successful hydrothiomethylation reactions, the best results are obtained with monosubstituted 1-alkenes. In these cases, the reactions take place with excellent regioselectivity and give branched hydrothiomethylation products exclusively (23 examples). When dimethyl sulfide is used as a substrate, either the monohydrothiomethylation product or the dihydrothiomethylation product can be obtained with very good selectivity."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pagination":["e03427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12759164"],"repository":["biostudies-literature"],"pubmed_title":["Titanium-Catalyzed Intermolecular Hydrothiomethylation of Alkenes."],"pmcid":["PMC12759164"],"pubmed_authors":["Thye H","Fornfeist F","Schluschen LL","Doye S"],"additional_accession":[]},"is_claimable":false,"name":"Titanium-Catalyzed Intermolecular Hydrothiomethylation of Alkenes.","description":"A catalyst screening for six different α-alkylation reactions of methyl sulfides with unsaturated substrates performed in hermetically sealable and inexpensive 42-well aluminum reactor blocks is described. As a result, a new titanium-catalyzed hydrothiomethylation reaction of alkenes, which takes place under C─H bond activation at the α-carbon atom of simple methyl sulfides, is presented. The best catalyst is prepared in situ from the readily available titanium catalyst precursor Ti(CH<sub>2</sub>SiMe<sub>3</sub>)<sub>4</sub>, a formamidinato ligand precursor, and the Lewis acid [Ph<sub>3</sub>C][B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>]. Although selected 1,2-disubstituted alkenes, for example, cyclohexene and cyclopentene, undergo successful hydrothiomethylation reactions, the best results are obtained with monosubstituted 1-alkenes. In these cases, the reactions take place with excellent regioselectivity and give branched hydrothiomethylation products exclusively (23 examples). When dimethyl sulfide is used as a substrate, either the monohydrothiomethylation product or the dihydrothiomethylation product can be obtained with very good selectivity.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T09:39:29.981Z","creation":"2026-05-28T03:11:58.668Z"},"accession":"S-EPMC12759164","cross_references":{"pubmed":["41311225"],"doi":["10.1002/chem.202503427"]}}