{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ballerini L"],"funding":["China Scholarship Council","Ministry of University and Research","Agence Nationale de la Recherche","National Recovery and Resilience Plan","PRIN2022 scheme"],"pagination":["e10787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12759247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(1)"],"pubmed_abstract":["The development of efficient circularly polarized electrochemiluminescence (CP-ECL) probes is still at its infancy and examples are still very limited. Yet, their achievement would enable gathering a readout that carries privileged information on the probe's chiral environment by monitoring luminescence polarization bias with high signal-to-noise ratio. Notwithstanding, this is a highly challenging task and requires judicious chemical engineering of chiral ECL-active emitters. Herein, we aim at expanding the palette of CP-ECL luminophores by presenting a novel class of enantiopure heterobinuclear Ir(III)-Au(I) complexes, which are investigated thoroughly by means of chemical, structural, and (chiro-)optical techniques. The ground and excited state properties are also elucidated by using density functional theory (DFT) approaches including spin-orbital coupling (SOC) perturbation. The chiral-at-metal complexes display luminescence with a polarization bias of the emitted light that is function of the helical arrangement of the coordination sphere around the Ir(III) center. Overall, the photo- and electro-active complexes unraveled in this work combine unparallelly high photoluminescence quantum yield in the orange region, excellent circularly polarized luminescence (CPL) brightness up to 4.5 M<sup>-1</sup> cm<sup>-1</sup> with a notable ECL activity. Finally, these features provide emitters with CP-ECL efficiency that encompass remarkably by a factor 3.5 that of the well-known benchmark tris-(2,2'-bipyridyl)ruthenium(II)."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Bright Circularly Polarized Electrochemiluminescence from Heterobinuclear Ir&lt;sup&gt;III&lt;/sup&gt;-Au&lt;sup&gt;I&lt;/sup&gt; Enantiomers."],"pmcid":["PMC12759247"],"funding_grant_id":["2022YYPTZS","ANR‐24‐CE29‐2108","ANR‐21‐CE29‐0015","ANR-24-CE29-2108","ANR-21-CE29-0015"],"pubmed_authors":["Sojic N","Di Bari L","Ballerini L","Liu M","Cesar V","Bellemin-Laponnaz S","Zinna F","Mauro M","Arrico L","Gourlaouen C","Voci S","Daniel C","Polo F","Bouffier L"],"additional_accession":[]},"is_claimable":false,"name":"Bright Circularly Polarized Electrochemiluminescence from Heterobinuclear Ir&lt;sup&gt;III&lt;/sup&gt;-Au&lt;sup&gt;I&lt;/sup&gt; Enantiomers.","description":"The development of efficient circularly polarized electrochemiluminescence (CP-ECL) probes is still at its infancy and examples are still very limited. Yet, their achievement would enable gathering a readout that carries privileged information on the probe's chiral environment by monitoring luminescence polarization bias with high signal-to-noise ratio. Notwithstanding, this is a highly challenging task and requires judicious chemical engineering of chiral ECL-active emitters. Herein, we aim at expanding the palette of CP-ECL luminophores by presenting a novel class of enantiopure heterobinuclear Ir(III)-Au(I) complexes, which are investigated thoroughly by means of chemical, structural, and (chiro-)optical techniques. The ground and excited state properties are also elucidated by using density functional theory (DFT) approaches including spin-orbital coupling (SOC) perturbation. The chiral-at-metal complexes display luminescence with a polarization bias of the emitted light that is function of the helical arrangement of the coordination sphere around the Ir(III) center. Overall, the photo- and electro-active complexes unraveled in this work combine unparallelly high photoluminescence quantum yield in the orange region, excellent circularly polarized luminescence (CPL) brightness up to 4.5 M<sup>-1</sup> cm<sup>-1</sup> with a notable ECL activity. Finally, these features provide emitters with CP-ECL efficiency that encompass remarkably by a factor 3.5 that of the well-known benchmark tris-(2,2'-bipyridyl)ruthenium(II).","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T09:27:12.928Z","creation":"2026-05-28T03:11:55.748Z"},"accession":"S-EPMC12759247","cross_references":{"pubmed":["41230989"],"doi":["10.1002/anie.202510787"]}}