{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang'ondu RW"],"funding":["U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)","American Society of Hematology (ASH)","NCI NIH HHS"],"pagination":["1595-1606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12759290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(7)"],"pubmed_abstract":["Genomic alterations of IKZF1 are common and associated with adverse clinical features in B-progenitor acute lymphoblastic leukemia (B-ALL). The relationship between the type of IKZF1 alteration, B-ALL genomic subtype and outcome are incompletely understood. B-ALL subtype and genomic alterations were determined using transcriptome and genomic sequencing, and SNP microarray analysis in 688 pediatric patients with B-ALL in the St. Jude Total Therapy XV and 16 studies. IKZF1 alterations were identified in 115 (16.7%) patients, most commonly in BCR::ABL1 (78%) and CRLF2-rearranged, BCR::ABL1-like B-ALL (70%). These alterations were associated with 5-year cumulative incidence of relapse (CIR) of 14.8 ± 3.3% compared to 5.0 ± 0.9% for patients without any IKZF1 alteration (P < 0.0001). In separate multivariable analyses adjusting for genetic subtype groups and other factors, IKZF1 deletions of exons 4-7 (P = 0.0002), genomic IKZF1<sup>plus</sup> with any IKZF1 deletion (P = 0.006) or with focal IKZF1 deletion (P = 0.0007), and unfavorable genomic subtypes (P < 0.005) were independently adverse prognostic factors. Associations of genomic IKZF1<sup>plus</sup> and exon 4-7 deletions with adverse outcomes were confirmed in an independent cohort. The type of IKZF1 alteration, together with the subtype, are informative for risk stratification and to predict response in patients with B-ALL."],"journal":["Leukemia"],"pubmed_title":["Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia."],"pmcid":["PMC12759290"],"funding_grant_id":["U24 CA114766","P30 CA015704","U10 CA98543, U10 CA180886, U10 CA98413, U10 CA180899, U24 CA114766, U24-CA196173","U10 CA098413","U10 CA098543","CA015704","P30 CA021765","U10 CA180886","American Society of Hematology Minority Hematology Fellow award","R35 CA197695","U10 CA180899","U24 CA196173","P30 CA021765 and R35 CA197695"],"pubmed_authors":["Chang TC","Angiolillo A","Jeha S","Inaba H","Schore RJ","Burke MJ","Pui CH","Maloney K","Larsen E","Loh ML","Wu G","Devidas M","Salzer W","Roberts KG","Evans W","Ashcraft E","Cheng C","Yang J","Fan Y","Crews KR","Relling MV","Brady SW","Mattano L","Pounds S","Yang W","Mullighan CG","Wang'ondu RW"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.","description":"Genomic alterations of IKZF1 are common and associated with adverse clinical features in B-progenitor acute lymphoblastic leukemia (B-ALL). The relationship between the type of IKZF1 alteration, B-ALL genomic subtype and outcome are incompletely understood. B-ALL subtype and genomic alterations were determined using transcriptome and genomic sequencing, and SNP microarray analysis in 688 pediatric patients with B-ALL in the St. Jude Total Therapy XV and 16 studies. IKZF1 alterations were identified in 115 (16.7%) patients, most commonly in BCR::ABL1 (78%) and CRLF2-rearranged, BCR::ABL1-like B-ALL (70%). These alterations were associated with 5-year cumulative incidence of relapse (CIR) of 14.8 ± 3.3% compared to 5.0 ± 0.9% for patients without any IKZF1 alteration (P < 0.0001). In separate multivariable analyses adjusting for genetic subtype groups and other factors, IKZF1 deletions of exons 4-7 (P = 0.0002), genomic IKZF1<sup>plus</sup> with any IKZF1 deletion (P = 0.006) or with focal IKZF1 deletion (P = 0.0007), and unfavorable genomic subtypes (P < 0.005) were independently adverse prognostic factors. Associations of genomic IKZF1<sup>plus</sup> and exon 4-7 deletions with adverse outcomes were confirmed in an independent cohort. The type of IKZF1 alteration, together with the subtype, are informative for risk stratification and to predict response in patients with B-ALL.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-06T10:40:25.943Z","creation":"2026-05-29T03:12:52.303Z"},"accession":"S-EPMC12759290","cross_references":{"pubmed":["40360879"],"doi":["10.1038/s41375-025-02633-3"]}}