biostudies-literatureUnknown26(1)Yu S<h4>Background</h4>Radiation Dermatitis (RD) is the most common side effect of radiotherapy, severely affecting the implementation of the antitumor treatment plan. The traditional Chinese medicine(TCM) compound Danxiong Granules (TDX105) is an external formulation used clinically for over a decade with notable efficacy, though its pharmacological mechanisms remain unclear, This study delves into the intricate mechanism by which TDX105 confers protection against RD by modulating the inflammation-related pathway, employing a combination of network pharmacology and experimental validation.<h4>Methods</h4>The active components and potential targets of TDX105 were gathered from databases such as TCMSP, PubChem, PharmMapper and Swiss Target Prediction, disease-related target genes were collectedBMC complementary medicine and therapies4https://www.ebi.ac.uk/biostudies/studies/S-EPMC12763944biostudies-literatureMechanisms of traditional Chinese medicine compound Danxiong granules for the treatment of radiation dermatitis based on network pharmacology, molecular docking and experimental validation.PMC12763944Liu XXu KWu MCao HYu SHu XHuan YMa YLiu SFeng CDu NTian AfalseMechanisms of traditional Chinese medicine compound Danxiong granules for the treatment of radiation dermatitis based on network pharmacology, molecular docking and experimental validation.<h4>Background</h4>Radiation Dermatitis (RD) is the most common side effect of radiotherapy, severely affecting the implementation of the antitumor treatment plan. The traditional Chinese medicine(TCM) compound Danxiong Granules (TDX105) is an external formulation used clinically for over a decade with notable efficacy, though its pharmacological mechanisms remain unclear, This study delves into the intricate mechanism by which TDX105 confers protection against RD by modulating the inflammation-related pathway, employing a combination of network pharmacology and experimental validation.<h4>Methods</h4>The active components and potential targets of TDX105 were gathered from databases such as TCMSP, PubChem, PharmMapper and Swiss Target Prediction, disease-related target genes were collected2025-01-01T00:00:00Z2025 Nov2026-05-28T03:22:24.828Z2026-05-28T03:12:41.418ZS-EPMC127639444131626010.1186/s12906-025-05194-1