{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu JR"],"funding":["Taipei Medical University"],"pagination":["2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12764038"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Opioid-related oversedation is associated with respiratory depression and can lead to potentially catastrophic adverse events in hospitalized patients. This study aimed to investigate influential factors for postoperative sedation during morphine-based intravenous patient-controlled analgesia (IV-PCA).<h4>Methods</h4>We enrolled patients who received morphine-based IV-PCA for postoperative pain at a medical hospital between January 2020 and November 2022. The primary outcome was unintentional sedation within 72 h after surgery. The Observer Assessment of Alertness/Sedation Scale (OAA/S) was used to assess the sedation depth at 12-hour intervals. Multivariable logistic regression models were used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (CI)"],"journal":["BMC anesthesiology"],"pubmed_title":["Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain."],"pmcid":["PMC12764038"],"funding_grant_id":["TMU110-AE1-B11"],"pubmed_authors":["Wu JR","Chen JT","Wu HL","Wu YM","Cata JP","Cherng YG","Tai YH"],"additional_accession":[]},"is_claimable":false,"name":"Risk factors for morphine-associated sedation in intravenous patient-controlled analgesia for postoperative pain.","description":"<h4>Background</h4>Opioid-related oversedation is associated with respiratory depression and can lead to potentially catastrophic adverse events in hospitalized patients. This study aimed to investigate influential factors for postoperative sedation during morphine-based intravenous patient-controlled analgesia (IV-PCA).<h4>Methods</h4>We enrolled patients who received morphine-based IV-PCA for postoperative pain at a medical hospital between January 2020 and November 2022. The primary outcome was unintentional sedation within 72 h after surgery. The Observer Assessment of Alertness/Sedation Scale (OAA/S) was used to assess the sedation depth at 12-hour intervals. Multivariable logistic regression models were used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (CI)","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T10:32:19.425Z","creation":"2026-05-29T03:11:53.579Z"},"accession":"S-EPMC12764038","cross_references":{"pubmed":["41286757"],"doi":["10.1186/s12871-025-03520-1"]}}