{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chui MH"],"funding":["National Cancer Institute","NCI NIH HHS","National Institutes of Health"],"pagination":["100629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12764310"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["The current paradigm implicates a fallopian tube precursor as the origin of most ovarian high-grade serous carcinomas (HGSCs). However, a rare subset of HGSCs develop via a distinct pathway from low-grade serous ovarian neoplasms (namely, serous borderline tumors and low-grade serous carcinoma). This alternate pathway for the development of HGSC and other poorly differentiated carcinomas of the ovary is not well understood. To elucidate the molecular pathogenesis and evolutionary trajectory of histologic transformation of low-grade serous neoplasms, we performed whole exome sequencing on microdissected low-grade and higher-grade components from 7 cases of serous borderline tumor or low-grade serous carcinoma associated with a synchronous or metachronous indeterminate/high-grade carcinoma. "],"journal":["Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc"],"pubmed_title":["Early Genetic Divergence of High-Grade Carcinomas Originating from Low-Grade Serous Ovarian Neoplasms."],"pmcid":["PMC12764310"],"funding_grant_id":["P30CA008748 S5","P30 CA008748","RO1 CA260628","U2CCA271891","P50 CA228991"],"pubmed_authors":["Zhu J","Wang TL","Shih IM","Wang B","Song Q","Chui MH","Wang Y","Jiao Y","Vang R"],"additional_accession":[]},"is_claimable":false,"name":"Early Genetic Divergence of High-Grade Carcinomas Originating from Low-Grade Serous Ovarian Neoplasms.","description":"The current paradigm implicates a fallopian tube precursor as the origin of most ovarian high-grade serous carcinomas (HGSCs). However, a rare subset of HGSCs develop via a distinct pathway from low-grade serous ovarian neoplasms (namely, serous borderline tumors and low-grade serous carcinoma). This alternate pathway for the development of HGSC and other poorly differentiated carcinomas of the ovary is not well understood. To elucidate the molecular pathogenesis and evolutionary trajectory of histologic transformation of low-grade serous neoplasms, we performed whole exome sequencing on microdissected low-grade and higher-grade components from 7 cases of serous borderline tumor or low-grade serous carcinoma associated with a synchronous or metachronous indeterminate/high-grade carcinoma. ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-06T09:48:07.207Z","creation":"2026-05-28T03:12:29.618Z"},"accession":"S-EPMC12764310","cross_references":{"pubmed":["39389422"],"doi":["10.1016/j.modpat.2024.100629"]}}