{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ashraf M"],"funding":["NIDDK NIH HHS"],"pagination":["534-539"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12764355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(4)"],"pubmed_abstract":["<h4>Purpose</h4>To compare Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity on ultrawide field (UWF) colour imaging (CI) and UWF fluorescein angiography (FA).<h4>Design</h4>Cross-sectional retrospective review.<h4>Subjects</h4>Patients with diabetes mellitus and at least mild non-proliferative DR on UWF-CI.<h4>Methods</h4>UWF-CI and UWF-FA images acquired within 1 month of each other were evaluated independently using ETDRS DR Severity Scale (DRSS) for colour photography adapted for UWF-CI and UWF-FA. Extent of non-perfusion (NP, mm<sup>2</sup>) was determined from UWF-FA images.<h4>Main outcome measures</h4>Agreement rate between DRSS on UWF-CI and UWF-FA.<h4>Results</h4>Images from 218 eyes of 137 patients with diabetes were evaluated. Agreement rate for DRSS between UWF-CI and UWF-FA was moderate to substantial (K=0.46, Kw=0.65). Over-all, DRSS was worse in 73 (33.5%) eyes on UWF-FA and in 16 (7.3%) on UWF-CI. Compared to UWF-CI, UWF-FA identified more severe DRSS in 26.5% (1 step) and 7.34% (≥2 steps) of eyes. DRSS was worse than UWF-FA in 56 (51.4%) in early DR (ETDRS levels 20-47, N=109) and 17 (15.6%) in eyes with severe DR (53 and higher, N=109). In this cohort, the extent of NP significantly increased as eyes approach moderate non-proliferative DR (levels 43-47, p=0.0065).<h4>Conclusion</h4>When evaluating UWF-FA images using the ETDRS colour severity scale, DRSS is graded as more severe in a substantial number of eyes than when evaluating UWF-CI. It is uncertain how the DRSS levels using UWF-FA translate to clinical outcomes, but the additional lesions detected might provide added prognostic value. These and other recent data emphasise the need of obtaining outcome data based on UWF-FA and the potential need to develop DRSS specifically tailored for UWF-FA images."],"journal":["The British journal of ophthalmology"],"pubmed_title":["Evaluation of diabetic retinopathy severity on ultrawide field colour images compared with ultrawide fluorescein angiograms."],"pmcid":["PMC12764355"],"funding_grant_id":["P30 DK036836"],"pubmed_authors":["Pitoc CM","Aiello LP","Silva PS","Shokrollahi S","AbdelAl O","Ashraf M"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of diabetic retinopathy severity on ultrawide field colour images compared with ultrawide fluorescein angiograms.","description":"<h4>Purpose</h4>To compare Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity on ultrawide field (UWF) colour imaging (CI) and UWF fluorescein angiography (FA).<h4>Design</h4>Cross-sectional retrospective review.<h4>Subjects</h4>Patients with diabetes mellitus and at least mild non-proliferative DR on UWF-CI.<h4>Methods</h4>UWF-CI and UWF-FA images acquired within 1 month of each other were evaluated independently using ETDRS DR Severity Scale (DRSS) for colour photography adapted for UWF-CI and UWF-FA. Extent of non-perfusion (NP, mm<sup>2</sup>) was determined from UWF-FA images.<h4>Main outcome measures</h4>Agreement rate between DRSS on UWF-CI and UWF-FA.<h4>Results</h4>Images from 218 eyes of 137 patients with diabetes were evaluated. Agreement rate for DRSS between UWF-CI and UWF-FA was moderate to substantial (K=0.46, Kw=0.65). Over-all, DRSS was worse in 73 (33.5%) eyes on UWF-FA and in 16 (7.3%) on UWF-CI. Compared to UWF-CI, UWF-FA identified more severe DRSS in 26.5% (1 step) and 7.34% (≥2 steps) of eyes. DRSS was worse than UWF-FA in 56 (51.4%) in early DR (ETDRS levels 20-47, N=109) and 17 (15.6%) in eyes with severe DR (53 and higher, N=109). In this cohort, the extent of NP significantly increased as eyes approach moderate non-proliferative DR (levels 43-47, p=0.0065).<h4>Conclusion</h4>When evaluating UWF-FA images using the ETDRS colour severity scale, DRSS is graded as more severe in a substantial number of eyes than when evaluating UWF-CI. It is uncertain how the DRSS levels using UWF-FA translate to clinical outcomes, but the additional lesions detected might provide added prognostic value. These and other recent data emphasise the need of obtaining outcome data based on UWF-FA and the potential need to develop DRSS specifically tailored for UWF-FA images.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-06T10:37:36.499Z","creation":"2026-05-29T03:11:58.255Z"},"accession":"S-EPMC12764355","cross_references":{"pubmed":["36669774"],"doi":["10.1136/bjo-2022-322163"]}}