biostudies-literatureYan WShingling Liao Ning Revitalization Talents ProgramKey R&D Program of Liaoning ProvinceKey R&D Program of Liaoning ProvinceNatural Science Foundation of Liaoning ProvinceNational Natural Science Foundation of Chinathe 345 Talent Project in Shengjing Hospital of China Medical University6315-6326https://www.ebi.ac.uk/biostudies/studies/S-EPMC12764643biostudies-literatureUnknown104(12)Light-chain (AL) amyloidosis is a rare disease and its early diagnosis remains challenging. This study aimed to develop an artificial intelligence (AI)-based diagnostic assistance system to improve the early diagnosis of AL amyloidosis and facilitate earlier and more precise disease management. Through cooperation with 18 hospitals in the Chinese Registration Network for Light-chain Amyloidosis (CRNLA), 1,355 patients with AL amyloidosis were registered and followed up from January 2010 to January 2022. Ten variables that are easily monitored in clinics, including age, cardiac troponin I (cTnl), N-terminal prohormone B-type natriuretic peptide (NT-ProBNP), creatinine (Crea), albumin (ALB), total bilirubin (Tbil), alkaline phosphatase (ALP), interventricular septum (IVS), left ventricular pAnnals of hematologyDevelopment of an artificial intelligence-based early diagnostic system for light-chain amyloidosis.PMC12764643Nos. 61972079 and 617721262019JH2/101000272022-YGJC-61;2022-MS-219XLYC1802100Wen YLi JLi CChen JSun CWang HXu HYan WLiu XJin FLi YHe TChen ZGao LLiu BWang XLi BZhong LfalseDevelopment of an artificial intelligence-based early diagnostic system for light-chain amyloidosis.Light-chain (AL) amyloidosis is a rare disease and its early diagnosis remains challenging. This study aimed to develop an artificial intelligence (AI)-based diagnostic assistance system to improve the early diagnosis of AL amyloidosis and facilitate earlier and more precise disease management. Through cooperation with 18 hospitals in the Chinese Registration Network for Light-chain Amyloidosis (CRNLA), 1,355 patients with AL amyloidosis were registered and followed up from January 2010 to January 2022. Ten variables that are easily monitored in clinics, including age, cardiac troponin I (cTnl), N-terminal prohormone B-type natriuretic peptide (NT-ProBNP), creatinine (Crea), albumin (ALB), total bilirubin (Tbil), alkaline phosphatase (ALP), interventricular septum (IVS), left ventricular p2025-01-01T00:00:00Z2025 Dec2026-05-29T03:14:32.108Z2026-05-29T03:11:23.9ZS-EPMC127646434122502310.1007/s00277-025-06674-7