biostudies-literatureUnknown16Seiyama AThe low-magnification optical coherence tomography (LM-OCT) is expected to enable the quantification of tissue glucose concentration (TGC) by maintaining high spatial resolution while reducing artifacts caused by tissue heterogeneity. In the present study, we report the practical application of LM-OCT using a conventional OCT system, i.e., without compromising spatial resolution, for the selective monitoring of changes in TGC through <i>in vivo</i> experiments using a hairless rat model. A commercially available high-spatial resolution OCT device with a center wavelength of 1300 nm was used to detect the three-dimensional (3D) skin surface structure and the scattering coefficient related to the OCT slope. The grand-averaged OCT signal was employed to estimate the OCT slope, while the origiMethodsX103752https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765054biostudies-literatureAn approach to <i>in vivo</i> low-magnification optical coherence tomography for selective monitoring of tissue glucose concentration.PMC12765054Wei FOhmi MSeiyama AfalseAn approach to <i>in vivo</i> low-magnification optical coherence tomography for selective monitoring of tissue glucose concentration.The low-magnification optical coherence tomography (LM-OCT) is expected to enable the quantification of tissue glucose concentration (TGC) by maintaining high spatial resolution while reducing artifacts caused by tissue heterogeneity. In the present study, we report the practical application of LM-OCT using a conventional OCT system, i.e., without compromising spatial resolution, for the selective monitoring of changes in TGC through <i>in vivo</i> experiments using a hairless rat model. A commercially available high-spatial resolution OCT device with a center wavelength of 1300 nm was used to detect the three-dimensional (3D) skin surface structure and the scattering coefficient related to the OCT slope. The grand-averaged OCT signal was employed to estimate the OCT slope, while the origi2026-01-01T00:00:00Z2026 Jun2026-06-10T04:58:52.976Z2026-06-10T03:07:40.333ZS-EPMC127650544149240710.1016/j.mex.2025.103752