{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(1)"],"submitter":["Guo W"],"pubmed_abstract":["Human adenovirus type 14p1 (HAdV-14p1) is associated with severe respiratory illness. Using human airway organoids, we characterized the cellular tropism, infection dynamics, and cellular response to HAdV-14p1, and evaluated the antiviral efficacy of cidofovir. HAdV-14p1 robustly infected and replicated in human airway organoids, particularly targeting ciliated, basal, and goblet cells. CCL5, CXCL10, CXCL11, and TNFSF13B were significantly upregulated upon HAdV-14p1 infection, indicating inflammatory activation. Pathway enrichment analysis revealed that upregulated genes were enriched in p53 signaling, cytokine-cytokine receptor interaction, and NOD-like receptor signaling pathways, whereas downregulated genes were linked to focal adhesion, tight junction, metabolic pathways, and oxidative"],"journal":["iScience"],"pagination":["114323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765093"],"repository":["biostudies-literature"],"pubmed_title":["Tropism, replication competence, and cellular responses of HAdV-14p1 in human airway organoids."],"pmcid":["PMC12765093"],"pubmed_authors":["Peng X","Chen Q","Liu L","Liang Y","Guo W","Lin W","Lin Y","Li L","Wen T","Li Y","Yang Y","Lin C","Cui F","Wang Y","Chen R","Zhou J","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"Tropism, replication competence, and cellular responses of HAdV-14p1 in human airway organoids.","description":"Human adenovirus type 14p1 (HAdV-14p1) is associated with severe respiratory illness. Using human airway organoids, we characterized the cellular tropism, infection dynamics, and cellular response to HAdV-14p1, and evaluated the antiviral efficacy of cidofovir. HAdV-14p1 robustly infected and replicated in human airway organoids, particularly targeting ciliated, basal, and goblet cells. CCL5, CXCL10, CXCL11, and TNFSF13B were significantly upregulated upon HAdV-14p1 infection, indicating inflammatory activation. Pathway enrichment analysis revealed that upregulated genes were enriched in p53 signaling, cytokine-cytokine receptor interaction, and NOD-like receptor signaling pathways, whereas downregulated genes were linked to focal adhesion, tight junction, metabolic pathways, and oxidative","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T04:58:49.586Z","creation":"2026-06-10T03:07:39.239Z"},"accession":"S-EPMC12765093","cross_references":{"pubmed":["41492463"],"doi":["10.1016/j.isci.2025.114323"]}}