biostudies-literatureZamantakis ANCATS NIH HHSNIAID NIH HHSNIMH NIH HHSNational Institutes of HealthNIH HHSNIGMS NIH HHS558-570https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765568biostudies-literatureUnknown30(2)<h4>Background</h4>Same-day pre-exposure prophylaxis (PrEP) for HIV prevention is a novel tool to increase biomedical prevention access and uptake. Although prior research has identified same-day PrEP as feasible and acceptable, improved understanding of key barriers and facilitators to implementation is needed to optimize impact.<h4>Methods</h4>The Network for Implementation Science in HIV (NISH) examined the implementation of same-day PrEP across 42 Ryan White Part A-D-funded organizations in seven Ending the U.S. HIV Epidemic Initiative priority jurisdictions. We used crisp-set coincidence analysis with six conditions to identify key barriers explaining delayed implementation of same-day PrEP among 38 clinical organizations representing 137 individual clinics where same-day PrEP serviceAIDS and behaviorBarriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in Federally Funded HIV Clinics Within High-Burden Areas of the U.S.: A Coincidence Analysis.PMC12765568P30 AI027767K01 MH130244UL1 TR001422P30 MH062294P30 AI036214R25 MH083620P30AI117943, P30AI094189, P30MH062294, P30MH058107, P30AI036214, P30AI027767P20 GM125507P30 MH058107P30 AI117943P30 AI094189Valeriano TKao UNelson LEBenbow NDGomez WLee SJKassanits JBlumenthal JSZamantakis AJones JLKatomski ASSchwartz SRBeres LKRosen JGPachicano AMHumphries DLukose LBrewer RARosenberg-Carlson EPWillging CEKarris MRana AIHamilton AKemp CfalseBarriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in Federally Funded HIV Clinics Within High-Burden Areas of the U.S.: A Coincidence Analysis.<h4>Background</h4>Same-day pre-exposure prophylaxis (PrEP) for HIV prevention is a novel tool to increase biomedical prevention access and uptake. Although prior research has identified same-day PrEP as feasible and acceptable, improved understanding of key barriers and facilitators to implementation is needed to optimize impact.<h4>Methods</h4>The Network for Implementation Science in HIV (NISH) examined the implementation of same-day PrEP across 42 Ryan White Part A-D-funded organizations in seven Ending the U.S. HIV Epidemic Initiative priority jurisdictions. We used crisp-set coincidence analysis with six conditions to identify key barriers explaining delayed implementation of same-day PrEP among 38 clinical organizations representing 137 individual clinics where same-day PrEP service2026-01-01T00:00:00Z2026 Feb2026-07-16T18:42:52.383Z2026-07-11T03:08:34.472ZS-EPMC127655684107150410.1007/s10461-025-04898-2