biostudies-literatureUnknown39(1)Yoon SH<h4>Background</h4>Inadequate pain control after robot-assisted laparoscopic radical prostatectomy (RALP) can impair recovery and quality of life. The acetaminophen/ibuprofen combination is a useful component of opioid-sparing analgesia, but the optimal timing of administration remains unclear. This study aimed to compare preemptive and preventive administration of this combination in RALP patients.<h4>Methods</h4>Adult patients undergoing RALP under general anesthesia were enrolled. Patients were randomized in a 1:1 ratio to receive acetaminophen 1,000 mg and ibuprofen 300 mg in 100 mL solution either before incision (preemptive group) or at the end of surgery (preventive group). The primary outcome was cumulative fentanyl consumption via intravenous patient-controlled analgesia within 24The Korean journal of pain125-135https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765643biostudies-literatureComparison of the postoperative opioid-sparing effect between preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted laparoscopic radical prostatectomy: a double-blind randomized controlled trial.PMC12765643Yoon SHYoon SLee HJBahk JCho SfalseComparison of the postoperative opioid-sparing effect between preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted laparoscopic radical prostatectomy: a double-blind randomized controlled trial.<h4>Background</h4>Inadequate pain control after robot-assisted laparoscopic radical prostatectomy (RALP) can impair recovery and quality of life. The acetaminophen/ibuprofen combination is a useful component of opioid-sparing analgesia, but the optimal timing of administration remains unclear. This study aimed to compare preemptive and preventive administration of this combination in RALP patients.<h4>Methods</h4>Adult patients undergoing RALP under general anesthesia were enrolled. Patients were randomized in a 1:1 ratio to receive acetaminophen 1,000 mg and ibuprofen 300 mg in 100 mL solution either before incision (preemptive group) or at the end of surgery (preventive group). The primary outcome was cumulative fentanyl consumption via intravenous patient-controlled analgesia within 242026-01-01T00:00:00Z2026 Jan2026-06-06T11:03:45.903Z2026-05-29T03:12:39.047ZS-EPMC127656434146921710.3344/kjp.25308