{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(2)"],"submitter":["Zhou Y"],"pubmed_abstract":["<h4>Background</h4>Accurate preoperative identification of high-volume central lymph node metastasis (hv-CLNM; defined as more than 5 central lymph node metastases) is critical for guiding surgical decisions-lobectomy or total thyroidectomy-in patients with papillary thyroid carcinoma (PTC) clinically diagnosed with central neck lymph node metastasis (cN1a). Total thyroidectomy is generally preferred for patients with hv-CLNM. In contrast, lobectomy may be sufficient for patients with low-volume metastasis (5 or fewer lymph node metastases). This study aimed to identify predictors of hv-CLNM in preoperatively low-risk cN1a and to develop a predictive model to estimate the risk of hv-CLNM, thereby optimizing surgical decision-making.<h4>Methods</h4>A total of 707 patients with pathologicall"],"journal":["Annals of surgical oncology"],"pagination":["1307-1318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765736"],"repository":["biostudies-literature"],"pubmed_title":["Surgical Optimization in Preoperatively Low-risk cN1a PTC: A Predictive Model for High-Volume Central Lymph Node Metastasis."],"pmcid":["PMC12765736"],"pubmed_authors":["Guo Z","Hu Y","Long J","Ke Z","Chen W","Liang M","Li R","Zhou Y","Xu H","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Surgical Optimization in Preoperatively Low-risk cN1a PTC: A Predictive Model for High-Volume Central Lymph Node Metastasis.","description":"<h4>Background</h4>Accurate preoperative identification of high-volume central lymph node metastasis (hv-CLNM; defined as more than 5 central lymph node metastases) is critical for guiding surgical decisions-lobectomy or total thyroidectomy-in patients with papillary thyroid carcinoma (PTC) clinically diagnosed with central neck lymph node metastasis (cN1a). Total thyroidectomy is generally preferred for patients with hv-CLNM. In contrast, lobectomy may be sufficient for patients with low-volume metastasis (5 or fewer lymph node metastases). This study aimed to identify predictors of hv-CLNM in preoperatively low-risk cN1a and to develop a predictive model to estimate the risk of hv-CLNM, thereby optimizing surgical decision-making.<h4>Methods</h4>A total of 707 patients with pathologicall","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-06T10:48:51.883Z","creation":"2026-05-29T03:11:46.18Z"},"accession":"S-EPMC12765736","cross_references":{"pubmed":["41125985"],"doi":["10.1245/s10434-025-18569-y"]}}