biostudies-literatureUnknown6(12)Lin RApproximately 20% of acute myocardial infarction (AMI) patients with multivessel disease experience adverse outcomes after complete revascularization. We aim to investigate the underlying metabolic mechanism of ischemia-reperfusion injury responsible for abnormal hemodynamic stresses in high-risk patients undergoing complete revascularization. Elevated preoperative serum levels of long-chain acylcarnitine (LCAC) 16:1 are associated with an increased risk of poor prognosis following complete revascularization. Multi-omics analyses reveal that reperfusion injury activates fatty acid degradation, and carnitine palmitoyltransferase 1A (CPT1A) is identified as a key regulator of LCACs in the interaction network in porcine models. In the early stages of reperfusion injury in non-culprit lesions,Cell reports. Medicine102507https://www.ebi.ac.uk/biostudies/studies/S-EPMC12765950biostudies-literatureTargeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization.PMC12765950Yin WLin RQin JLi FGao HWang LLi YTan XRen LChen WWang XDu JWang YYang SWang ZfalseTargeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization.Approximately 20% of acute myocardial infarction (AMI) patients with multivessel disease experience adverse outcomes after complete revascularization. We aim to investigate the underlying metabolic mechanism of ischemia-reperfusion injury responsible for abnormal hemodynamic stresses in high-risk patients undergoing complete revascularization. Elevated preoperative serum levels of long-chain acylcarnitine (LCAC) 16:1 are associated with an increased risk of poor prognosis following complete revascularization. Multi-omics analyses reveal that reperfusion injury activates fatty acid degradation, and carnitine palmitoyltransferase 1A (CPT1A) is identified as a key regulator of LCACs in the interaction network in porcine models. In the early stages of reperfusion injury in non-culprit lesions,2025-01-01T00:00:00Z2025 Dec2026-06-06T11:16:28.569Z2026-05-29T03:12:42.379ZS-EPMC127659504140694510.1016/j.xcrm.2025.102507