{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou LH"],"funding":["Key Clinical Frontier Technology Project of the Department of Science and Technology of Jiangsu","Innovative Research Group Project of the National Natural Science Foundation of China","National Natural Science Foundation of China"],"pagination":["e05820"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12767070"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The neonatal heart possesses the unique ability to regenerate post-injury. Underlying related mechanisms and reactivation of this process are crucial for regeneration medicine. Using quantitative proteomics with tandem mass tag labeling, RNA-sequencing (RNA-seq) and single-nucleus RNA-seq dataset analyses, high mobility group box 2 (HMGB2) is identified as a key regulator of cardiomyocyte proliferation, whose expression declines during postnatal heart development and increases in the high regenerative potential cardiomyocyte populations in hearts post-injury. Cardiomyocyte-specific HMGB2 knockdown curtails cardiomyocyte proliferation and impairs heart regeneration following apical resection in neonatal mice, while cardiomyocyte-specific HMGB2 overexpression enhances cardiomyocyte prolifera"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2-Driven Metabolic Reprogramming."],"pmcid":["PMC12767070"],"funding_grant_id":["BE2022806","82121001","82370344"],"pubmed_authors":["Zhang XZ","Wang LS","Jing P","Chen YX","Bao YL","Wang H","Wang SB","Zhao Y","Xie LP","Yang TT","Zhou LH","Gu LF","Shan TK","He Y","Du C","Wang QM","Chen JY","Ji Y"],"additional_accession":[]},"is_claimable":false,"name":"HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2-Driven Metabolic Reprogramming.","description":"The neonatal heart possesses the unique ability to regenerate post-injury. Underlying related mechanisms and reactivation of this process are crucial for regeneration medicine. Using quantitative proteomics with tandem mass tag labeling, RNA-sequencing (RNA-seq) and single-nucleus RNA-seq dataset analyses, high mobility group box 2 (HMGB2) is identified as a key regulator of cardiomyocyte proliferation, whose expression declines during postnatal heart development and increases in the high regenerative potential cardiomyocyte populations in hearts post-injury. Cardiomyocyte-specific HMGB2 knockdown curtails cardiomyocyte proliferation and impairs heart regeneration following apical resection in neonatal mice, while cardiomyocyte-specific HMGB2 overexpression enhances cardiomyocyte prolifera","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T11:05:35.84Z","creation":"2026-05-29T03:13:02.431Z"},"accession":"S-EPMC12767070","cross_references":{"pubmed":["41092376"],"doi":["10.1002/advs.202505820"]}}