{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Prabhudesai S"],"pubmed_abstract":["Endothelial cells (ECs) in the brain communicate with mural cells to facilitate vascular stability. Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) signaling mechanism at EC-mural cell interface helps stabilize the vasculature. How this paracrine signaling is mediated is not known. Our laboratory studies endothelial cilia, a microtubule-based organelle, and its role in promoting vascular stability. We discovered that brain endothelial cilia are located primarily on the basolateral side, and PDGF-BB is expressed in EC cilium. Thus, we hypothesized that endothelium cilium in conjunction with PDGF-BB on the basolateral side is responsible for mural cell recruitment. In this study, using a combination of zebrafish, mice, and human brain model sys"],"journal":["Life science alliance"],"pagination":["e202503460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12769094"],"repository":["biostudies-literature"],"pubmed_title":["Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side of endothelium."],"pmcid":["PMC12769094"],"pubmed_authors":["Yang H","Zhang F","Dordick JS","Yang J","Girolamo F","Prabhudesai S","Virgintino D","Spearman AD","Rarick KR","Ramchandran R","Wang L","Errede M","Neumann T","Pan AY","Alvarez CA","Thirugnanam K","Marzullo A","Bafti S","Song X","Vanderhoef K"],"additional_accession":[]},"is_claimable":false,"name":"Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side of endothelium.","description":"Endothelial cells (ECs) in the brain communicate with mural cells to facilitate vascular stability. Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) signaling mechanism at EC-mural cell interface helps stabilize the vasculature. How this paracrine signaling is mediated is not known. Our laboratory studies endothelial cilia, a microtubule-based organelle, and its role in promoting vascular stability. We discovered that brain endothelial cilia are located primarily on the basolateral side, and PDGF-BB is expressed in EC cilium. Thus, we hypothesized that endothelium cilium in conjunction with PDGF-BB on the basolateral side is responsible for mural cell recruitment. In this study, using a combination of zebrafish, mice, and human brain model sys","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-06-06T10:56:42.678Z","creation":"2026-05-29T03:13:03.816Z"},"accession":"S-EPMC12769094","cross_references":{"pubmed":["41490797"],"doi":["10.26508/lsa.202503460"]}}