biostudies-literatureJeong DNational Institutes of Health National Cancer InstituteNCI NIH HHS112241https://www.ebi.ac.uk/biostudies/studies/S-EPMC12771776biostudies-literatureUnknown190<h4>Background</h4>Body composition is associated with colorectal cancer (CRC) survival. However, body composition measurements have traditionally relied on single-slice, axial imaging. Fully automated volumetric body composition analysis is widely available, but associations with CRC survival have yet to be examined in detail.<h4>Methods</h4>Among a nested case-control sample of CRC patients with existing CT scans, volumetric and single-slice body composition analysis was performed, including total area and proportional skeletal muscle (SM), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and intermuscular adipose tissue (IMAT). Body composition was measured from the T12 vertebra to the sacrum, with the mid-L3 level used for single-slice analysis. We used multivariable CEuropean journal of radiologyComparison of volumetric and single-slice computed tomography body composition metrics for colorectal cancer survival.PMC12771776P30 CA076292Toriola ATGigic BKresovich JKShibata DJeong DSiegel EMJean-Baptiste EGomez MFStewart PAFigueiredo JCThomas KLLi CIMo QRichards ARUlrich CMByrd DAfalseComparison of volumetric and single-slice computed tomography body composition metrics for colorectal cancer survival.<h4>Background</h4>Body composition is associated with colorectal cancer (CRC) survival. However, body composition measurements have traditionally relied on single-slice, axial imaging. Fully automated volumetric body composition analysis is widely available, but associations with CRC survival have yet to be examined in detail.<h4>Methods</h4>Among a nested case-control sample of CRC patients with existing CT scans, volumetric and single-slice body composition analysis was performed, including total area and proportional skeletal muscle (SM), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and intermuscular adipose tissue (IMAT). Body composition was measured from the T12 vertebra to the sacrum, with the mid-L3 level used for single-slice analysis. We used multivariable C2025-01-01T00:00:00Z2025 Sep2026-06-06T10:50:32.815Z2026-05-29T03:11:45.068ZS-EPMC127717764053259210.1016/j.ejrad.2025.112241